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Verfasst von:Moinzadeh, Pia [VerfasserIn]   i
 Riemekasten, Gabriela [VerfasserIn]   i
 Siegert, Elise [VerfasserIn]   i
 Fierlbeck, Gerhard [VerfasserIn]   i
 Henes, Jörg Christoph [VerfasserIn]   i
 Blank, Norbert [VerfasserIn]   i
 Melchers, Inga [VerfasserIn]   i
 Müller-Ladner, Ulf [VerfasserIn]   i
 Frerix, Marc [VerfasserIn]   i
 Kreuter, Alexander [VerfasserIn]   i
 Tigges, Christian [VerfasserIn]   i
 Lahner, Nina Simone [VerfasserIn]   i
 Susok, Laura [VerfasserIn]   i
 Günther, Claudia [VerfasserIn]   i
 Warschat, Gabriele [VerfasserIn]   i
 Pfeiffer, Christiane [VerfasserIn]   i
 Worm, Margitta [VerfasserIn]   i
 Karrer, Sigrid [VerfasserIn]   i
 Aberer, Elisabeth [VerfasserIn]   i
 Bretterklieber, Agnes [VerfasserIn]   i
 Genth, Ekkehard [VerfasserIn]   i
 Simon, Jan C. [VerfasserIn]   i
 Distler, Joerg H.W. [VerfasserIn]   i
 Hein, Ruediger [VerfasserIn]   i
 Schneider, Matthias [VerfasserIn]   i
 Seitz, Cornelia S. [VerfasserIn]   i
 Herink, Claudia [VerfasserIn]   i
 Steinbrink, Kerstin [VerfasserIn]   i
 Sárdy, Miklos [VerfasserIn]   i
 Varga, Rita [VerfasserIn]   i
 Mensing, Hartwig [VerfasserIn]   i
 Mensing, Christian [VerfasserIn]   i
 Lehmann, Percy [VerfasserIn]   i
 Neeck, Gunther [VerfasserIn]   i
 Fiehn, Christoph [VerfasserIn]   i
 Weber, Manfred [VerfasserIn]   i
 Goebeler, Matthias [VerfasserIn]   i
 Burkhardt, Harald [VerfasserIn]   i
 Buslau, Michael [VerfasserIn]   i
 Ahmadi-Simab, Keihan [VerfasserIn]   i
 Himsel, Andrea [VerfasserIn]   i
 Juche, Aaron [VerfasserIn]   i
 Koetter, Ina [VerfasserIn]   i
 Kuhn, Annegret [VerfasserIn]   i
 Sticherling, Michael [VerfasserIn]   i
 Hellmich, Martin [VerfasserIn]   i
 Kuhr, Kathrin [VerfasserIn]   i
 Krieg, Thomas [VerfasserIn]   i
 Ehrchen, Jan [VerfasserIn]   i
 Sunderkoetter, Cord [VerfasserIn]   i
 Hunzelmann, Nicolas [VerfasserIn]   i
Titel:Vasoactive therapy in systemic sclerosis
Titelzusatz:real-life therapeutic practice in more than 3000 patients
Verf.angabe:Pia Moinzadeh, Gabriela Riemekasten, Elise Siegert, Gerhard Fierlbeck, Joerg Henes, Norbert Blank, Inga Melchers, Ulf Mueller-Ladner, Marc Frerix, Alexander Kreuter, Christian Tigges, Nina Lahner, Laura Susok, Claudia Guenther, Gabriele Zeidler, Christiane Pfeiffer, Margitta Worm, Sigrid Karrer, Elisabeth Aberer, Agnes Bretterklieber, Ekkehard Genth, Jan C. Simon, Joerg H. W. Distler, Ruediger Hein, Matthias Schneider, Cornelia S. Seitz, Claudia Herink, Kerstin Steinbrink, Miklos Sárdy, Rita Varga, Hartwig Mensing, Christian Mensing, Percy Lehmann, Gunther Neeck, Christoph Fiehn, Manfred Weber, Matthias Goebeler, Harald Burkhardt, Michael Buslau, Keihan Ahmadi-Simab, Andrea Himsel, Aaron Juche, Ina Koetter, Annegret Kuhn, Michael Sticherling, Martin Hellmich, Kathrin Kuhr, Thomas Krieg, Jan Ehrchen, Cord Sunderkoetter, and Nicolas Hunzelmann, The German Network for Systemic Scleroderma
E-Jahr:2016
Jahr:January 1, 2016
Umfang:9 S.
Titel Quelle:Enthalten in: The journal of rheumatology
Ort Quelle:Toronto, Ont., 2001
Jahr Quelle:2016
Band/Heft Quelle:43(2016), 1, Seite 66-74
ISSN Quelle:1499-2752
Abstract:Objective. Vasculopathy is a key factor in the pathophysiology of systemic sclerosis (SSc) and the main cause for Raynaud phenomenon (RP), digital ulcers (DU), and/or pulmonary arterial hypertension (PAH). It is so far unknown how patients with SSc are treated with vasoactive agents in daily practice. To determine to which extent patients with SSc were treated with different vasoactive agents, we used data from the German Network for Systemic Scleroderma registry. - Methods. The data of 3248 patients with SSc were analyzed. - Results. Patients were treated with vasoactive drugs in 61.1% of cases (1984/3248). Of these, 47.6% received calcium channel inhibitors, followed by 34.2% treated with angiotensin-converting enzyme (ACE) inhibitors, 21.1% treated with intravenous (IV) prostanoids, 10.1% with pentoxifylline, 8.8% with angiotensin 1 receptor antagonists (AT1RA), 8.7% with endothelin 1 receptor antagonists (ET1RA), 4.1% with phosphodiesterase type 5 (PDE5) inhibitors, and 5.3% with others. Patients with RP received vasoactive therapy in 63.3% of cases, with DU in 70.1%, and with PAH in 78.2% of cases. Logistic regression analysis revealed that patients with PAH were significantly more often treated with PDE5 inhibitors and ET1RA, and those with DU with ET1RA and IV prostanoids. In addition, 41.8% of patients were treated with ACE inhibitors and/or AT1RA. Patients registered after 2009 received significantly more often ET1RA, AT1RA, and IV prostanoids compared with patients registered prior to 2005. - Conclusion. These data clearly indicate that many patients with SSc do not yet receive sufficient vasoactive therapy. Further, in recent years, a marked change of treatment regimens can be observed.
DOI:doi:10.3899/jrheum.150382
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3899/jrheum.150382
 Volltext: http://www.jrheum.org/content/43/1/66.long
 DOI: https://doi.org/10.3899/jrheum.150382
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:GERMAN NETWORK FOR SYSTEMIC SCLERODERMA
 REAL LIFE
 SYSTEMIC SCLEROSIS
 VASOACTIVE THERAPY
K10plus-PPN:102370756X
Verknüpfungen:→ Zeitschrift

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