Exploiting common aspects of obesity and cancer cachexia for future therapeutic strategies

• Verfasst von: Molocea, Claudia-Eveline [VerfasserIn]
• Verfasst von: Tsokanos, Foivos Filippos [VerfasserIn]
• Verfasst von: Herzig, Stephan [VerfasserIn]
• Titel: Exploiting common aspects of obesity and cancer cachexia for future therapeutic strategies
• Verf.angabe: Claudia-Eveline Molocea, Foivos-Filippos Tsokanos and Stephan Herzig
• E-Jahr: 2020
• Jahr: 29 August 2020
• Umfang: 16 S.
• Fussnoten: Gesehen am 19.01.2021
• Titel Quelle: Enthalten in: Current opinion in pharmacology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 2001
• Jahr Quelle: 2020
• Band/Heft Quelle: 53(2020), Seite 101-116
• ISSN Quelle: 1471-4973
• DOI: doi:10.1016/j.coph.2020.07.006
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1744940991

Abstract

Obesity and cancer cachexia are diseases at opposite ends of the BMI. However, despite the apparent dichotomy, these pathologies share some common underlying mechanisms that lead to profound metabolic perturbations. Insulin resistance, adipose tissue lipolysis, skeletal muscle atrophy and systemic inflammation are key players in both diseases. Several strategies for pharmacological treatments have been employed in obesity and cancer cachexia but demonstrated only limited effects. Therefore, there is still a need to develop novel, more effective strategies. In this review we summarize existing therapies and discuss potential novel strategies that could arise by bridging common aspects between obesity and cachexia. We discuss the potential role of macrophage manipulation and the modulation of inflammation by targeting Nuclear Receptors (NRs) as potential novel therapeutic strategies.