Motor dysfunction and sensorimotor cortex activation changes in schizophrenia

• Verfasst von: Schröder, Johannes [VerfasserIn]
• Verfasst von: Essig, Marco [VerfasserIn]
• Verfasst von: Baudendistel, Klaus [VerfasserIn]
• Verfasst von: Jahn, Thomas [VerfasserIn]
• Verfasst von: Gerdsen, Ingo [VerfasserIn]
• Verfasst von: Stockert, Andreas [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Knopp, Michael V. [VerfasserIn]
• Titel: Motor dysfunction and sensorimotor cortex activation changes in schizophrenia
• Titelzusatz: a study with functional magnetc resonance imaging
• Verf.angabe: Johannes Schröder, Marco Essig, Klaus Baudendistel, Thomas Jahn, Ingo Gerdsen, Andreas Stockert, Lothar R. Schad, Michael V. Knopp
• E-Jahr: 2002
• Jahr: 25 May 2002
• Jahr des Originals: 1999
• Umfang: 7 S.
• Fussnoten: Available online 25 May 2002 ; Gesehen am 25.01.2021
• Titel Quelle: Enthalten in: NeuroImage
• Ort Quelle: Orlando, Fla. : Academic Press, 1992
• Jahr Quelle: 1999
• Band/Heft Quelle: 9(1999), 1, Seite 81-87
• ISSN Quelle: 1095-9572
• DOI: doi:10.1006/nimg.1998.0387
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: functional magnetic resonance imaging
• Sach-SW: neurological soft signs
• Sach-SW: schizophrenia
• Sach-SW: sensorimotor cortex
• Sach-SW: supplementary motor area.
• K10plus-PPN: 174553542X

Abstract

Recent studies demonstrate a diminished activation of the sensorimotor cortex and supplementary motor area (SMA) in schizophrenia which may be involved in the pathogenesis of neurological soft signs (NSS). Yet, the question whether a retarded motor performance may account for these changes remained to be clarified. Twelve DSM-III-R schizophrenics and 12 healthy controls were included. All subjects were right-handed. Nine patients received clozapine, two conventional neuroleptics, and one was drug-free. Functional magnetic resonance imaging (fMRI) was obtained in a resting condition and during pronation/supination at three speed levels (low, medium, and high) with motor performance recorded simultaneously using a pronation/supination device. While measures of motor retardation (i.e., repetition rate and amplitude of the movements) did not differ between patients and controls, the variability of performance was significantly (P<0.05) increased in the patients' group. In addition, patients with schizophrenia showed a significantly (P<0.05) decreased activation of the sensorimotor cortices. Similar, although nonsignificant (P=0.09) activation changes were observed in the SMA. Activation differences were more pronounced at a slow speed and in the drug-free patient. These results confirm a diminished sensorimotor cortex and SMA activation and indicate that variability of performance rather than retarded performance per se may correspond to these changes.