Influence of antipsychotic and anticholinergic loads on cognitive functions in patients with schizophrenia

• Verfasst von: Rehse, Michael [VerfasserIn]
• Verfasst von: Bartolovic, Marina [VerfasserIn]
• Verfasst von: Weisbrod, Matthias [VerfasserIn]
• Verfasst von: Roesch-Ely, Daniela [VerfasserIn]
• Titel: Influence of antipsychotic and anticholinergic loads on cognitive functions in patients with schizophrenia
• Verf.angabe: Michael Rehse, Marina Bartolovic, Katlehn Baum, Dagmar Richter, Matthias Weisbrod, and Daniela Roesch-Ely
• E-Jahr: 2016
• Jahr: 10 Apr 2016
• Umfang: 10 S.
• Teil: year:2016
• Teil: pages:8213165
• Teil: extent:10
• Fussnoten: Gesehen am 26.01.2021
• Titel Quelle: Enthalten in: Schizophrenia research and treatment
• Ort Quelle: New York, NY [u.a.] : Hindawi, 2011
• Jahr Quelle: 2016
• Band/Heft Quelle: (2016) Artikel-Nummer 8213165, 10 Seiten
• ISSN Quelle: 2090-2093
• DOI: doi:10.1155/2016/8213165
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1745537317

Abstract

Many patients with schizophrenia show cognitive impairment. There is evidence that, beyond a certain dose of antipsychotic medication, the antipsychotic daily dose (ADD) may impair cognitive performance. Parallel to their D2 receptor antagonism, many antipsychotics show a significant binding affinity to cholinergic muscarinic receptors. Pharmacological treatment with a high anticholinergic daily dose (CDD) significantly impairs attention and memory performance. To examine the relationships between individual cognitive performance and ADD and/or CDD, we conducted a retrospective record-based analysis of a sample of in patients with a diagnosis of schizophrenia, all of whom had completed a comprehensive neuropsychological test battery. To calculate the individual ADD and CDD, the medication at the time of testing was converted according to equivalence models. After extracting five principal cognitive components, we examined the impact of ADD and CDD on cognitive performance in the medicated sample and subgroups using multiple regression analysis. Finally, locally weighted scatterplot smoothing (Loess) was applied to further explore the course of cognitive performance under increasing dosage. Results showed significant negative effects of ADD on performance in tests of information processing speed and verbal memory. No effects were found for CDD. The potential neuropsychopharmacological and clinical implications are discussed.