Comparison of functional MR-venography and EPI-BOLD fMRI at 1.5 t

• Verfasst von: Baudendistel, Klaus [VerfasserIn]
• Verfasst von: Reichenbach, Jürgen [VerfasserIn]
• Verfasst von: Metzner, Roland [VerfasserIn]
• Verfasst von: Schröder, Johannes [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Titel: Comparison of functional MR-venography and EPI-BOLD fMRI at 1.5 t
• Verf.angabe: Klaus T. Baudendistel, Jürgen R. Reichenbach, Roland Metzner, Johannes Schroeder, Lothar R. Schad
• E-Jahr: 1998
• Jahr: 8 December 1998
• Umfang: 3 S.
• Fussnoten: Gesehen am 25.01.2021
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 1998
• Band/Heft Quelle: 16(1998), 8, Seite 989-9914
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/S0730-725X(98)00085-X
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Functional MRI
• Sach-SW: Motor cortex stimulation
• Sach-SW: MR-venography
• Sach-SW: Susceptibility effect
• K10plus-PPN: 174559051X

Abstract

Functional magnetic resonance imaging (fMRI) of the brain using blood oxygenation level dependent (BOLD) contrast relies on the changes of paramagnetic deoxyhemoglobin concentration, which affects brain parenchyma and draining venous vessels. These changes in deoxyhemoglobin concentration in venous vessels can also be monitored using a high-resolution susceptibility-based MR-venography technique. Four volunteers participated in the study in which functional MR-venograms were compared with conventional echo-planar imaging (EPI)-BOLD-fMRI. In all cases, small venous vessels could be identified close to the areas of activation detected by conventional fMRI. In the venograms, task performance (finger tapping) resulted in a loss of venous vessel contrast compared to the resting state, which is consistent with a local decrease of deoxyhemoglobin concentration. MR-venography allows a direct visualization of the BOLD-effect at high spatial resolution. In combination with conventional fMRI, this technique may help to separate the contribution of brain parenchyma and venous vessels in fMRI studies.