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| Verfasst von: | Schröder, Johannes [VerfasserIn]  |
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| | Fauth Silvestri, Simone [VerfasserIn] |
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| | Bubeck, Bernd [VerfasserIn] |
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| | Karr, Markus [VerfasserIn] |
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| | Demisch, Sibylle [VerfasserIn] |
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| | Scherrer, Sabine [VerfasserIn] |
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| | Geider, Franz Josef [VerfasserIn] |
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| | Sauer, Heinrich [VerfasserIn] |
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| Titel: | D2 dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia |
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| Titelzusatz: | a follow-up study with 123I-Iodobenzamide single photon emission computed tomography in the drug-naive state and after neuroleptic treatment |
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| Verf.angabe: | Johannes Schröder, Simone Silvestri, Bernd Bubeck, Markus Karr, Sibylle Demisch, Sabine Scherrer, Franz J Geider, Heinrich Sauer |
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| E-Jahr: | 1998 |
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| Jahr: | 20 July 1998 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 26.01.2021 |
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| Titel Quelle: | Enthalten in: Biological psychiatry |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
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| Jahr Quelle: | 1998 |
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| Band/Heft Quelle: | 43(1998), 9, Seite 660-665 |
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| ISSN Quelle: | 1873-2402 |
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| Abstract: | Background: Animal and postmortem studies indicate that neuroleptic therapy may induce D2 dopamine receptor up-regulation in the basal ganglia. Methods: To address this phenomenon in a clinical study, we investigated the D2 dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state and 3 days after completion of a standardized neuroleptic therapy (benperidol 12-16 mg/day, for 25 days) using single photon emission computed tomography (SPECT). SPECT scans were obtained 2 hours after intravenous injection of 185 MBq 123I-iodobenzamide. For analysis, basal ganglia to frontal cortex (BG/FC) ratios were calculated and the patient sample was subgrouped into patients with a favorable versus a poor treatment response. Results: Neuroleptic treatment led to decreased BG/FC ratios in patients with a favorable response, but increased ratios in the poor responders (df = 1, F = 4.1, p = .06). Changes of BG/FC ratios were significantly correlated with extrapyramidal side effects but not with neurological soft signs. Conclusions: Our findings suggest that neuroleptic therapy may induce D2 dopamine receptor up-regulation in a subgroup of patients characterized by poor treatment response and pronounced extrapyramidal side effects. |
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| DOI: | doi:10.1016/S0006-3223(97)00442-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S0006-3223(97)00442-3 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0006322397004423 |
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| | DOI: https://doi.org/10.1016/S0006-3223(97)00442-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | D dopamine receptor up-regulation |
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| | extrapyramidal side effects |
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| | neurological soft signs |
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| | Schizophrenia |
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| | single photon emission computed tomography |
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| | treatment response |
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| K10plus-PPN: | 1745625097 |
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| Verknüpfungen: | → Zeitschrift |
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D2 dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia / Schröder, Johannes [VerfasserIn]; 20 July 1998 (Online-Ressource)
