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Verfasst von:Roesch-Ely, Daniela [VerfasserIn]   i
 Weiland, Stephan [VerfasserIn]   i
 Scheffel, Hans Ernst Wilhelm [VerfasserIn]   i
 Schwaninger, Markus [VerfasserIn]   i
 Hundemer, Hans-Peter [VerfasserIn]   i
 Kolter, Thomas [VerfasserIn]   i
 Weisbrod, Matthias [VerfasserIn]   i
Titel:Dopaminergic modulation of semantic priming in healthy volunteers
Verf.angabe:Daniela Roesch-Ely, Stephan Weiland, Hans Scheffel, Markus Schwaninger, Hans-Peter Hundemer, Thomas Kolter, Matthias Weisbrod
E-Jahr:2006
Jahr:5 April 2006
Umfang:8 S.
Fussnoten:Gesehen am 26.01.2021
Titel Quelle:Enthalten in: Biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1985
Jahr Quelle:2006
Band/Heft Quelle:60(2006), 6, Seite 604-611
ISSN Quelle:1873-2402
Abstract:Background - Semantic priming is a function related to prefrontal cortical (PFC) networks and is lateralized. There is evidence that semantic priming underlies dopaminergic modulation. It is known that the D1-receptor is more abundant in prefrontal networks; however, until now there have been no studies investigating the selective modulation of semantic priming with dopamine agonists. Furthermore, D1 receptor dysfunction has been described in schizophrenia, and patients with formal thought disorder seem to have disturbed focusing of associations and increased indirect priming. - Methods - With a subtraction design, we compared the influence of pergolide (D1/D2 agonist) with bromocriptine (D2 agonist) and placebo, in a randomized, double-blind, crossover design in 40 healthy male volunteers. Subjects performed a lateralized lexical decision task including direct and indirect related prime-target pairs (stimulus onset asynchrony = 750 msec). - Results - Only on pergolide a decrease of the indirect priming in the left hemisphere presentations was found. - Conclusions - These findings point to a potential selective modulation of agonists with a D1 component on the focusing of semantic associations. The clinical relevance of this study is that it might help the development of therapeutic strategies for treating cognitive deficits in schizophrenia and Parkinson’s disease, which are highly relevant to the functional outcome.
DOI:doi:10.1016/j.biopsych.2006.01.004
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.biopsych.2006.01.004
 Volltext: http://www.sciencedirect.com/science/article/pii/S0006322306001004
 DOI: https://doi.org/10.1016/j.biopsych.2006.01.004
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bromocriptine
 D1/D2 dopamine receptors
 dopamine agonists
 pergolide
 schizophrenia
 semantic priming
K10plus-PPN:1745627030
Verknüpfungen:→ Zeitschrift

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