Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis

• Verfasst von: Rehm, Martin [VerfasserIn]
• Verfasst von: Büchele, Gisela [VerfasserIn]
• Verfasst von: Peter, Raphael Simon [VerfasserIn]
• Verfasst von: Brenner, Rolf Erwin [VerfasserIn]
• Verfasst von: Günther, Klaus-Peter [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Koenig, Wolfgang [VerfasserIn]
• Verfasst von: Rothenbacher, Dietrich [VerfasserIn]
• Titel: Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
• Verf.angabe: Martin Rehm, Gisela Büchele, Raphael Simon Peter, Rolf Erwin Brenner, Klaus-Peter Günther, Hermann Brenner, Wolfgang Koenig, Dietrich Rothenbacher
• E-Jahr: 2020
• Jahr: December2, 2020
• Umfang: 13 S.
• Fussnoten: Gesehen am 26.01.2021
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2020
• Band/Heft Quelle: 15(2020,12) Artikel-Nummer e0242814, 13 Seiten
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0242814
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarkers
• Sach-SW: Cardiovascular disease risk
• Sach-SW: Cholesterol
• Sach-SW: Death rates
• Sach-SW: Diabetes mellitus
• Sach-SW: Hip
• Sach-SW: Osteoarthritis
• Sach-SW: Troponin
• K10plus-PPN: 1745633197

Abstract

Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the association of cardiac biomarker concentrations with long-term mortality in subjects with OA. In a cohort of 679 OA subjects, undergoing hip or knee replacement during 1995/1996, cardiac biomarkers were measured and subjects were followed over 20 years. During a median follow-up of 18.4 years, 332 (48.9%) subjects died. Median of hs-cTnT, hs-cTnI, and NT-proBNP at baseline was 3.2 ng/L, 3.9 ng/L, and 96.8 ng/L. The top quartile of NT-proBNP was associated with increased risk of mortality (Hazard Ratio (HR) 1.79, 95% confidence interval (CI) 1.17-2.73) after adjustment for covariates including troponins (hs-cTnT HR 1.30 (95% CI 0.90-1.89), hs-cTnI HR 1.32 (95% CI 0.87-2.00) for top category). When biomarker associations were evaluated as continuous variables, only NT-proBNP (HR per log-unit increment 1.34, 95% CI 1.16-1.54) and hs-cTnI (HR 1.38, 95% CI 1.11-1.72) showed robust results. Elevated cardiac biomarker concentrations predicted an increased risk of long-term mortality and strongest for NT-proBNP and hs-cTnI. These results might help to identify subjects at risk and target preventive efforts early.