Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation

• Verfasst von: Oellerich, Michael [VerfasserIn]
• Verfasst von: Shipkova, Maria [VerfasserIn]
• Verfasst von: Schütz, Ekkehard [VerfasserIn]
• Verfasst von: Wieland, Eberhard [VerfasserIn]
• Verfasst von: Weber, Lutz T. [VerfasserIn]
• Verfasst von: Tönshoff, Burkhard [VerfasserIn]
• Verfasst von: Armstrong, Victor W. [VerfasserIn]
• Titel: Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation
• Titelzusatz: implications for therapeutic drug monitoring
• Verf.angabe: Michael Oellerich, Maria Shipkova, Ekkehard Schütz, Eberhard Wieland, Lute Weber, Burkhard Tönshoff, Victor W. Armstrong
• E-Jahr: 2000
• Jahr: February 2000
• Umfang: 7 S.
• Fussnoten: Der Verfasser "Lutz Weber" wurde in der Verfasserliste falsch geschrieben ; Gesehen am 26.01.2021
• Titel Quelle: Enthalten in: Therapeutic drug monitoring
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1979
• Jahr Quelle: 2000
• Band/Heft Quelle: 22(2000), 1, Seite 20-26
• ISSN Quelle: 1536-3694
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1745692649

Abstract

The need for mycophenolic acid (MPA) monitoring is still under discussion. Key issues for the PK/PD relationships of this drug are: the role of metabolites, the usefulness of AUC versus predose levels, and the need to monitor the free concentration of MPA (f-MPA). Recent advances have revealed that, in addition to 7-O-MPAG, three additional MPA metabolites are present in the plasma of transplant recipients. One of these metabolites (M-2), identified as an acyl glucuronide of MPA, was found to inhibit IMPDH-II in vitro. This active metabolite was also found to cross-react in the Emit assay for MPA. In an ongoing multicenter study, the authors are evaluating the relevance of monitoring total (t-MPA) and free mycophenolic acid (f-MPA) in pediatric renal transplant recipients.