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Verfasst von:Frey, Felix [VerfasserIn]   i
 Schwarz, Ulrich S. [VerfasserIn]   i
Titel:Competing pathways for the invagination of clathrin-coated membranes
Verf.angabe:Felix Frey and Ulrich S. Schwarz
E-Jahr:2020
Jahr:20th October 2020
Umfang:11 S.
Fussnoten:Gesehen am 27.01.2021
Titel Quelle:Enthalten in: Soft matter
Ort Quelle:London : Royal Soc. of Chemistry, 2005
Jahr Quelle:2020
Band/Heft Quelle:16(2020), 47, Seite 10723-10733
ISSN Quelle:1744-6848
Abstract:Clathrin-mediated endocytosis is the major pathway by which eukaryotic cells take up extracellular material, but it is still elusive which physical pathways are being taken during membrane invagination. From a continuum point of view, it can be driven by increases in coat stiffness, preferred curvature or line tension. Here we develop a comprehensive theoretical framework that can be solved analytically and that predicts the consequences of these different scenarios. We find that for the case of increasing stiffness or preferred curvature, curvature will be acquired gradually with growth, while for increasing line tension, the lattice must have grown to a certain size before a flat-to-curved transition can occur. At low membrane tension, the critical value for coat stiffness is 30 kBT, for preferred curvature it is 200 nm, and for line tension it is 6 pN. For high membrane tension, critical coat stiffness is 150 kBT and critical preferred curvature is 70 nm. In the mixed case when a coat with finite rigidity but increasing line tension is considered, a cup-to-sphere transition can occur for a line tension of 6 pN. The flat-to-curved and the cup-to-sphere transitions driven by line tension are both suppressed by high membrane tension.
DOI:doi:10.1039/D0SM01375G
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1039/D0SM01375G
 Volltext: https://pubs.rsc.org/en/content/articlelanding/2020/sm/d0sm01375g
 DOI: https://doi.org/10.1039/D0SM01375G
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:174581745X
Verknüpfungen:→ Zeitschrift

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