Polydimethylsiloxane-based wide-range mass calibration for direct analysis in real-time mass spectrometry

• Verfasst von: Gross, Jürgen H. [VerfasserIn]
• Titel: Polydimethylsiloxane-based wide-range mass calibration for direct analysis in real-time mass spectrometry
• Verf.angabe: Jürgen H. Gross
• E-Jahr: 2013
• Jahr: 14 August 2013
• Umfang: 6 S.
• Fussnoten: Gesehen am 29.01.2021
• Titel Quelle: Enthalten in: Analytical and bioanalytical chemistry
• Ort Quelle: Berlin : Springer, 2002
• Jahr Quelle: 2013
• Band/Heft Quelle: 405(2013), 26, Seite 8663-8668
• ISSN Quelle: 1618-2650
• DOI: doi:10.1007/s00216-013-7287-1
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1745911162

Abstract

Direct analysis in real-time mass spectrometry (DART-MS) is normally applied for small-molecule analysis up to about m/z 1,000. Here, for the analysis of polydimethylsiloxanes, high-mass capabilities expanding beyond m/z 3,000 are demonstrated. In addition, polydimethylsiloxanes provide an ideal mass calibration standard for positive-ion DART-MS. A mass reference list has been compiled to cover ions from m/z 200 up to m/z 2,600. Species with more than 20 silicon atoms exhibit increasingly broader isotopic patterns with decreasing abundances of the monoisotopic ions. The use of the first isotopic peaks for analyte ions above m/z 2,000 serves as a work-around and ensures easy and reproducible recognition of the reference peaks by the instrument data system. Here, the positive-ion DART mass spectra of polydimethylsiloxanes and the corresponding experimental procedures are described, and the mass reference list is provided.