Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Caesar, Joseph J. E. [VerfasserIn]  |
| Wallich, Reinhard [VerfasserIn]  |
| Kraiczy, Peter [VerfasserIn]  |
| Zipfel, Peter F. [VerfasserIn]  |
| Lea, Susan M. [VerfasserIn]  |
Titel: | Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi |
Verf.angabe: | Joseph J.E. Caesar, Reinhard Wallich, Peter Kraiczy, Peter F. Zipfel and Susan M. Lea |
E-Jahr: | 2013 |
Jahr: | 9 May 2013 |
Umfang: | 5 S. |
Fussnoten: | Gesehen am 28.01.2021 |
Titel Quelle: | Enthalten in: Acta crystallographica / F |
Ort Quelle: | Oxford [u.a.] : Blackwell, 2005 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 69(2013), 6, Seite 629-633 |
ISSN Quelle: | 2053-230X |
| 1744-3091 |
Abstract: | B. burgdorferi binds complement factor H using a dimeric surface protein, CspA (BbCRASP-1). Presented here is a new structure of CspA that suggests that there is a degree of flexibility between subunits which may have implications for complement regulator binding., - Borrelia burgdorferi has evolved many mechanisms of evading the different immune systems across its range of reservoir hosts, including the capture and presentation of host complement regulators factor H and factor H-like protein-1 (FHL-1). Acquisition is mediated by a family of complement regulator-acquiring surface proteins (CRASPs), of which the atomic structure of CspA (BbCRASP-1) is known and shows the formation of a homodimeric species which is required for binding. Mutagenesis studies have mapped a putative factor H binding site to a cleft between the two subunits. Presented here is a new atomic structure of CspA which shows a degree of flexibility between the subunits which may be critical for factor H scavenging by increasing access to the binding interface and allows the possibility that the assembly can clamp around the bound complement regulators. |
DOI: | doi:10.1107/S1744309113012748 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1107/S1744309113012748 |
| Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668580/ |
| DOI: https://doi.org/10.1107/S1744309113012748 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1745938672 |
Verknüpfungen: | → Zeitschrift |
Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi / Caesar, Joseph J. E. [VerfasserIn]; 9 May 2013 (Online-Ressource)
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