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Verfasst von:Schmezer, Peter [VerfasserIn]   i
 Bartsch, Helmut [VerfasserIn]   i
Titel:Laryngeal mucosa of head and neck cancer patients shows increased DNA damage as detected by single cell microgel electrophoresis
Verf.angabe:P. Schmezer, T. Rupprecht, M. Tisch, H. Maier, H. Bartsch
E-Jahr:2000
Jahr:20 April 2000
Umfang:6 S.
Fussnoten:Gesehen am 02.02.2021
Titel Quelle:Enthalten in: Toxicology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1973
Jahr Quelle:2000
Band/Heft Quelle:144(2000), 1/3, Seite 149-154
ISSN Quelle:1879-3185
Abstract:Major risk factors for cancer of the oral cavity, pharynx and larynx are smoking and excess alcohol consumption. Since long-term survival rates of head and neck cancer patients have not substantially been improved, new preventive strategies including the use of cancer chemopreventive agents have to be developed. With the aim of developing biomarkers which can verify the efficacy of chemopreventive interventions, a standardised alkaline microgel electrophoresis (MGE) assay was applied as a sensitive and rapid tool to detect DNA damage on a single cell level. Macroscopically normal laryngeal mucosa biopsies obtained by surgery from head and neck cancer patients (n=29) and from hospital controls (n=22) were analysed by MGE in a pilot study. As compared to controls, cells from head and neck cancer patients showed a significantly elevated DNA damage without any further genotoxic treatment (P<0.01). We conclude that this increased background DNA damage in laryngeal epithelia could result from genetic alterations caused by smoking and alcohol leading, in accord with the field cancerisation hypothesis, to a gradual decrease of genomic stability and malignancy. MGE should now be explored as a rapid screening method in larger clinical studies: (i) to identify high-risk subjects carrying cells with decreased genomic stability and (ii) to verify the efficacy of chemopreventive regimens to prevent or slow down the development of head and neck cancer in high-risk persons.
DOI:doi:10.1016/S0300-483X(99)00201-2
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/S0300-483X(99)00201-2
 Volltext: http://www.sciencedirect.com/science/article/pii/S0300483X99002012
 DOI: https://doi.org/10.1016/S0300-483X(99)00201-2
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:DNA damage
 Head and neck cancer
 Microgel electrophoresis
K10plus-PPN:174668075X
Verknüpfungen:→ Zeitschrift

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