Ras gene mutations in vinyl chloride‐induced liver tumours are carcinogen‐specific but vary with cell type and species

• Verfasst von: Boivin-Angèle, Sandra [VerfasserIn]
• Verfasst von: Wegener, Kurt [VerfasserIn]
• Verfasst von: Bartsch, Helmut [VerfasserIn]
• Titel: Ras gene mutations in vinyl chloride‐induced liver tumours are carcinogen‐specific but vary with cell type and species
• Verf.angabe: Sandra Boivin‐Angèle, Lydie Lefrançois, Olivier Froment, Andreas Spiethoff, Matthew S. Bogdanffy, Kurt Wegener, Horst Wesch, Alain Barbin, Brigitte Bancel, Christian Trépo, Helmut Bartsch, James Swenberg and Marie-Jeanne Marion
• E-Jahr: 2000
• Jahr: 07 January 2000
• Umfang: 5 S.
• Fussnoten: Gesehen am 02.02.2021
• Titel Quelle: Enthalten in: International journal of cancer
• Ort Quelle: Bognor Regis : Wiley-Liss, 1966
• Jahr Quelle: 2000
• Band/Heft Quelle: 85(2000), 2, Seite 223-227
• ISSN Quelle: 1097-0215
• DOI: doi:10.1002/(SICI)1097-0215(20000115)85:2<223::AID-IJC12>3.0.CO;2-H
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1746681764

Abstract

Previous studies have shown that a high proportion (5/6) of human liver angiosarcomas (ASL) associated with exposure to vinyl chloride (VC) contains a GC→AT mutation at the Ki‐ras codon 13. This mutation, however, has not been found in 5 ASL or 2 hepatocellular carcinomas (HCC) induced in rats by VC.