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Verfasst von:Schröder, Johannes [VerfasserIn]   i
 Bubeck, Bernd [VerfasserIn]   i
 Fauth Silvestri, Simone [VerfasserIn]   i
 Demisch, Sibylle [VerfasserIn]   i
 Sauer, Heinrich [VerfasserIn]   i
Titel:Gender differences in D2 dopamine receptor binding in drug-naive patients with schizophrenia
Titelzusatz:an [123I]iodobenzamide single photon emission computed tomography study
Verf.angabe:Johannes Schröder, Bernd Bubeck, Simone Silvestri, Sibylle Demisch, Heinrich Sauer
Jahr:1997
Jahr des Originals:1998
Umfang:9 S.
Fussnoten:Available online 5 January 1998 ; Im Titel sind die Zahlen "123" hochgestellt ; Gesehen am 02.02.2021
Titel Quelle:Enthalten in: Psychiatry research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1979
Jahr Quelle:1997
Band/Heft Quelle:75(1997), 2, Seite 115-123
ISSN Quelle:1872-7123
Abstract:Recent studies have described a left lateralized striatal asymmetry of D2 dopamine receptors in male patients with schizophrenia. To replicate this finding and to explore its potential functional consequences, we investigated the D2 dopamine receptor system in 23 drug-naive patients with schizophrenia using single photon emission computed tomography (SPELT). Patients were examined in the drug-naive state and 72 h after completing a standardized neuroleptic treatment with benperidol (12-16 mg/day) for 25 days. Each SPELT examination comprised two scans: the first scan was taken 2 h after intravenous injection of 185 MBq [123I]iodobenzamide. After completion of the first scan, patients received benperidol (8 mg) intravenously. The second scan was started 20 min later. For analysis, basal ganglia to frontal cortex ratios were calculated. Fifteen of the 23 patients originally recruited completed the study on day 28. When compared to female patients, male patients showed a left lateralized asymmetry of striatal D2 dopamine receptor binding in the drug-naive state with an almost significant (P = 0.07) sex X hemisphere interaction. In the male patients, benperidol challenge led to a reversal of asymmetry patterns. These findings support previous reports of a left lateralized striatal D2 receptor binding in drug-naive male patients with schizophrenia and suggest that this asymmetry may affect the binding of conventional neuroleptics such as benperidol at the D2 dopamine receptor.
DOI:doi:10.1016/S0925-4927(97)00046-2
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/S0925-4927(97)00046-2
 Volltext: http://www.sciencedirect.com/science/article/pii/S0925492797000462
 DOI: https://doi.org/10.1016/S0925-4927(97)00046-2
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:D2 dopamine receptor
 Gender
 IBZM
 Schizophrenia
 SPELT
K10plus-PPN:1746693495
Verknüpfungen:→ Zeitschrift

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