Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Habtewold, Abiy [VerfasserIn]  |
| Riedel, Klaus-Dieter [VerfasserIn]  |
| Burhenne, Jürgen [VerfasserIn]  |
Titel: | Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients |
Verf.angabe: | A Habtewold, W Amogne, E Makonnen, G Yimer, H Nylén, K-D Riedel, G Aderaye, L Bertilsson, J Burhenne, U Diczfalusy and E Aklillu |
Jahr: | 2013 |
Jahr des Originals: | 2012 |
Umfang: | 6 S. |
Fussnoten: | Published: 23 October 2012 ; Gesehen am 09.02.2021 |
Titel Quelle: | Enthalten in: The pharmacogenomics journal |
Ort Quelle: | Basingstoke : Nature Publishing Group, 2001 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 13(2013), 6, Seite 484-489 |
ISSN Quelle: | 1473-1150 |
Abstract: | We investigated the effects of pharmacogenetic variations and efavirenz pharmacokinetics on inter-individual differences in the extent of CYP3A induction by efavirenz using 4β-hydroxycholesterol/cholesterol (4β-OHC/Chol) as a marker for CYP3A induction. Plasma 4β-hydroxycholesterol and cholesterol concentrations were determined at baseline, and at the 4th, 16th and 48th week of efavirenz-based highly active antiretroviral therapy in antiretroviral therapy-naive HIV patients (n=77). Efavirenz plasma concentrations were quantified at weeks 4 and 16. CYP2B6, CYP3A5, ABCB1, UGT2B7 genotyping were done. Compared with baseline, the median plasma 4β-OHC/Chol ratio increased at the 4th (257%), 16th (291%) and 48th (165%) week (P<0.0001). CYP2B6*6 genotype significantly influenced 4β-OHC/Chol ratio at weeks 16 (P=0.02) and 48 (P=0.04) being highest in CYP2B6*6/*6>*1/*6>*1/*1. There were positive correlations between plasma efavirenz and 4β-OHC/Chol ratios (week 4: P=0.02, week 16: P=0.001). CYP3A enzyme induction by efavirenz is pronounced in CYP2B6 slow metabolizers who have high efavirenz plasma exposure. |
DOI: | doi:10.1038/tpj.2012.46 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/tpj.2012.46 |
| Volltext: https://www.nature.com/articles/tpj201246 |
| DOI: https://doi.org/10.1038/tpj.2012.46 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1747169625 |
Verknüpfungen: | → Zeitschrift |
Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients / Habtewold, Abiy [VerfasserIn]; 2013 (Online-Ressource)
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