Monitoring contact sensitization to p-phenylenediamine (PPD) by patch testing with PPD 0.3 % in petrolatum

• Verfasst von: Geier, Johannes [VerfasserIn]
• Verfasst von: Ballmer-Weber, Barbara K. [VerfasserIn]
• Verfasst von: Dickel, Heinrich [VerfasserIn]
• Verfasst von: Frosch, Peter J. [VerfasserIn]
• Verfasst von: Bircher, Andreas [VerfasserIn]
• Verfasst von: Weisshaar, Elke [VerfasserIn]
• Verfasst von: Hillen, Uwe [VerfasserIn]
• Titel: Monitoring contact sensitization to p-phenylenediamine (PPD) by patch testing with PPD 0.3 % in petrolatum
• Verf.angabe: Johannes Geier, Barbara K. Ballmer‐Weber, Heinrich Dickel, Peter J. Frosch, Andreas Bircher, Elke Weisshaar and Uwe Hillen
• E-Jahr: 2013
• Jahr: 19 June 2013
• Umfang: 6 S.
• Fussnoten: Gesehen am 03.02.2020
• Titel Quelle: Enthalten in: Contact dermatitis
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1975
• Jahr Quelle: 2013
• Band/Heft Quelle: 69(2013), Seite 26-31
• ISSN Quelle: 1600-0536
• DOI: doi:10.1111/cod.12075
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: active sensitization
• Sach-SW: CAS 106-50-3
• Sach-SW: monitoring of contact allergy
• Sach-SW: p-phenylenediamine
• Sach-SW: patch test concentration
• Sach-SW: patch testing
• K10plus-PPN: 1747185582

Abstract

Background Being a contact allergen of general relevance, p-phenylenediamine (PPD) is patch tested in the baseline series. However, PPD 1% in petrolatum may actively sensitize. Patch testing with PPD at 0.35% pet. proved to be safe, as far as active sensitization is concerned. Objectives To determine whether PPD 0.3% pet. reliably detects PPD sensitization. Methods Patch testing with PPD 0.3% pet. and 1% pet. synchronously was performed in consecutive patients in a multicentre study within the Information Network of Departments of Dermatology. Results Altogether, 2042 patients were patch tested. PPD 1% pet. yielded 6.0% positive reactions (n = 123), and PPD 0.3% pet. yielded 4.7% (n = 95). The synchronous reproducibility of PPD reactions was similar as known from parallel patch tests with identical PPD concentrations. The diagnostic properties of PPD 0.3% pet. expressed as reaction index and positivity ratio were good. Of the 123 patients reacting to PPD 1% pet., 32 (26%) had no positive reaction to PPD 0.3% pet. In 22 of these 32 patients (69%), no clinical relevance could be found. Conclusions As patch testing with PPD 0.3% pet. is reliable according to our results, we recommend replacing PPD 1% pet. in the baseline series with PPD 0.3% pet.