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Status: Bibliographieeintrag

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Verfasst von:Hofmann, Thomas G. [VerfasserIn]   i
 Dröge, Wulf [VerfasserIn]   i
Titel:CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx
Verf.angabe:Thomas G. Hofmann, Andreas Möller, Steffen P. Hehner, Dominik Welsch, Wulf Dröge, and M. Lienhard Schmitz
E-Jahr:2001
Jahr:09 June 2001
Umfang:7 S.
Fussnoten:Gesehen am 03.02.2021
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2001
Band/Heft Quelle:93(2001), 2, Seite 185-191
ISSN Quelle:1097-0215
Abstract:Here we investigated CD95-mediated JNK activation pathways and their physiological relevance by employing a variety of cell lines with deficiencies in individual signal transmitting proteins. JNK activation was completely dependent on the activation of caspases in type I and type II cells, as revealed by the inhibitory effects of the caspase inhibitors zVAD-fmk or the cowpoxvirus-encoded CrmA protein. Jurkat cells deficient in caspase-8 or expressing a dominant negative (DN) form of FADD were unable to induce JNK in response to CD95 ligation, indicating that these death-inducing signaling complex (DISC) proteins are required for signal transmission. Activation of caspases, JNK and apoptosis occurred with a markedly slower kinetics in cells expressing a DN version of ASK1, revealing an important contribution of ASK1 for these processes. A C-terminally truncated version of Daxx impaired CD95-mediated apoptosis without affecting the JNK signal. DN forms of FADD, MKK4 and MKK7 completely inhibited CD95-mediated JNK activation but remained without impact on cell killing, indicating that JNK activation is not required for the execution process of CD95-mediated cell killing.
DOI:doi:10.1002/ijc.1316
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/ijc.1316
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.1316
 DOI: https://doi.org/10.1002/ijc.1316
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:apoptosis
 ASK1
 CD95 receptor
 DISC
 JNK
K10plus-PPN:1747188905
Verknüpfungen:→ Zeitschrift

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