Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Hofmann, Thomas G. [VerfasserIn]  |
| Dröge, Wulf [VerfasserIn]  |
Titel: | CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx |
Verf.angabe: | Thomas G. Hofmann, Andreas Möller, Steffen P. Hehner, Dominik Welsch, Wulf Dröge, and M. Lienhard Schmitz |
E-Jahr: | 2001 |
Jahr: | 09 June 2001 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 03.02.2021 |
Titel Quelle: | Enthalten in: International journal of cancer |
Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
Jahr Quelle: | 2001 |
Band/Heft Quelle: | 93(2001), 2, Seite 185-191 |
ISSN Quelle: | 1097-0215 |
Abstract: | Here we investigated CD95-mediated JNK activation pathways and their physiological relevance by employing a variety of cell lines with deficiencies in individual signal transmitting proteins. JNK activation was completely dependent on the activation of caspases in type I and type II cells, as revealed by the inhibitory effects of the caspase inhibitors zVAD-fmk or the cowpoxvirus-encoded CrmA protein. Jurkat cells deficient in caspase-8 or expressing a dominant negative (DN) form of FADD were unable to induce JNK in response to CD95 ligation, indicating that these death-inducing signaling complex (DISC) proteins are required for signal transmission. Activation of caspases, JNK and apoptosis occurred with a markedly slower kinetics in cells expressing a DN version of ASK1, revealing an important contribution of ASK1 for these processes. A C-terminally truncated version of Daxx impaired CD95-mediated apoptosis without affecting the JNK signal. DN forms of FADD, MKK4 and MKK7 completely inhibited CD95-mediated JNK activation but remained without impact on cell killing, indicating that JNK activation is not required for the execution process of CD95-mediated cell killing. |
DOI: | doi:10.1002/ijc.1316 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/ijc.1316 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.1316 |
| DOI: https://doi.org/10.1002/ijc.1316 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | apoptosis |
| ASK1 |
| CD95 receptor |
| DISC |
| JNK |
K10plus-PPN: | 1747188905 |
Verknüpfungen: | → Zeitschrift |
CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx / Hofmann, Thomas G. [VerfasserIn]; 09 June 2001 (Online-Ressource)
68687954