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| Verfasst von: | Haderk, Franziska [VerfasserIn]  |
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| | Hanna, Bola [VerfasserIn] |
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| | Richter, Karsten [VerfasserIn] |
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| | Schnölzer, Martina [VerfasserIn] |
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| | Zenz, Thorsten [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Seiffert, Martina [VerfasserIn] |
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| Titel: | Extracellular vesicles in chronic lymphocytic leukemia |
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| Verf.angabe: | Franziska Haderk, Bola Hanna, Karsten Richter, Martina Schnölzer, Thorsten Zenz, Stephan Stilgenbauer, Peter Lichter & Martina Seiffert |
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| E-Jahr: | 2013 |
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| Jahr: | 12 Jul 2013 |
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| Umfang: | 5 S. |
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| Fussnoten: | CLL Young Investigators' meeting 2012 ; Gesehen am 03.02.2021 |
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| Titel Quelle: | Enthalten in: Leukemia and lymphoma |
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| Ort Quelle: | London [u.a.] : Taylor & Francis Group, 1989 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 54(2013), 8, Seite 1826-1830 |
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| ISSN Quelle: | 1029-2403 |
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| Abstract: | Extracellular vesicles (EVs) are membrane-enclosed nanoparticles 30 to 1000 nm in size and represent a novel mechanism of cell communication. By transferring RNA and protein from their cell of origin, they can reprogram target cells and thus are involved in changes within the cellular microenvironment - a key player in CLL pathogenesis. In the current study, we were able to isolate EVs of 20 to 300 nm from blood plasma of CLL patients as well as from supernatant of primary CLL cells in culture. Further, proteomic profiling by Coomassie staining of SDS-PAGE gels and by mass spectrometry revealed an EV-specific protein profile. These findings suggest that EVs represent an important mean of CLL cells to interact with other cells, which might contribute to the establishment of a pro-survival microenvironment for CLL cells. |
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| DOI: | doi:10.3109/10428194.2013.796052 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3109/10428194.2013.796052 |
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| | DOI: https://doi.org/10.3109/10428194.2013.796052 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chronic lymphocytic leukemia |
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| | exosomes |
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| | extracellular vesicles |
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| | microenvironment |
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| | microvesicles |
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| | proteome |
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| K10plus-PPN: | 1747217131 |
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| Verknüpfungen: | → Zeitschrift |
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Extracellular vesicles in chronic lymphocytic leukemia / Haderk, Franziska [VerfasserIn]; 12 Jul 2013 (Online-Ressource)
