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Verfasst von:Dröge, Wulf [VerfasserIn]   i
Titel:Aging-related changes in the thiol/disulfide redox state
Titelzusatz:implications for the use of thiol antioxidants
Verf.angabe:Wulf Dröge
E-Jahr:2002
Jahr:4 October 2002
Umfang:13 S.
Fussnoten:Gesehen am 03.02.2021
Titel Quelle:Enthalten in: Experimental gerontology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1964
Jahr Quelle:2002
Band/Heft Quelle:37(2002), 12, Seite 1333-1345
ISSN Quelle:1873-6815
Abstract:Genetic and biochemical studies suggest that free radical-derived reactive oxygen species play a key role in a common mechanism of aging in many or all animal species. This led to the hypothesis that the quality of life in old age may be improved by pharmacological or dietary thiol antioxidants. This review describes important details about how the organism deals with its own thiol antioxidants. Aging was found to be associated with an oxidative shift in the thiol/disulfide redox state (REDST) of the intracellular glutathione pool and of the plasma cyst(e)ine and albumin pools. There is also a decrease in plasma thiol (mainly cysteine) concentration. The oxidative shift in intracellular REDST was found to be typically associated with cellular dysfunctions. Studies in humans related to plasma REDST revealed correlations with aging-related pathophysiological processes, suggesting that oxidative changes in REDST play a key role in processes and diseases which limit the human life span. The age-related shift in plasma REDST is mediated, at least partly, by the decreasing capacity to remove dietary cysteine from the oxidative environment of the blood. Thiol antioxidants were found to ameliorate various aging-related processes but obviously ought to be used with caution in consideration of the oxidative environment of the blood.
DOI:doi:10.1016/S0531-5565(02)00175-4
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/S0531-5565(02)00175-4
 Volltext: http://www.sciencedirect.com/science/article/pii/S0531556502001754
 DOI: https://doi.org/10.1016/S0531-5565(02)00175-4
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amino acid homeostasis and aging
 Cysteine homeostasis and aging
 Protein synthesis and aging
 Redox state and aging
 Thiol/disulfide redox state
K10plus-PPN:1747238791
Verknüpfungen:→ Zeitschrift

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