Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Hehner, Steffen Peter [VerfasserIn]  |
| Hofmann, Thomas G. [VerfasserIn]  |
| Dröge, Wulf [VerfasserIn]  |
Titel: | The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex |
Verf.angabe: | Steffen P. Hehner, Thomas G. Hofmann, Wulf Dröge, and M. Lienhard Schmitz |
E-Jahr: | 1999 |
Jahr: | November 15, 1999 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 03.02.2021 |
Titel Quelle: | Enthalten in: The journal of immunology |
Ort Quelle: | Bethesda, Md. : Soc., 1916 |
Jahr Quelle: | 1999 |
Band/Heft Quelle: | 163(1999), 10, Seite 5617-5623 |
ISSN Quelle: | 1550-6606 |
Abstract: | The transcription factor NF-κB is a key regulator of the cellular inflammatory and immune response. Therefore, components of the NF-κB-activating signaling pathways are frequent targets for antiinflammatory agents. This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-κB activation by preventing the TNF-α-induced induction of IκB kinase (IKK) and IKKβ, without affecting the activation of p38 and c-Jun N-terminal kinase. Parthenolide impairs NF-κB-dependent transcription triggered by expression of TNFR-associated factor-2, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEKK1), and NF-κB-inducing kinase. This compound also prevents activation of both IKKs and DNA binding of NF-κB induced by MEKK and NF-κB-inducing kinase. Parthenolide targets a component of the IκB kinase complex without directly inhibiting IKKα, IKKβ, or MEKK1. Therefore, this sesquiterpene lactone could serve as a lead compound for the development of antiinflammatory remedies and is suitable as a molecular tool, allowing the dissection of TNF-α-derived signaling pathways leading to the activation of NF-κB, c-Jun N-terminal kinase, and p38. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://www.jimmunol.org/content/163/10/5617 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1747242276 |
Verknüpfungen: | → Zeitschrift |
¬The¬ antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex / Hehner, Steffen Peter [VerfasserIn]; November 15, 1999 (Online-Ressource)
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