Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Elsing, Christoph [VerfasserIn]  |
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| | Herrmann, Christina [VerfasserIn] |
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| | Hannig, Carla Verena [VerfasserIn] |
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| | Stremmel, Wolfgang [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Herrmann, Thomas [VerfasserIn] |
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| Titel: | Sequential chemotherapies for advanced gastric cancer |
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| Titelzusatz: | a retrospective analysis of 111 patients |
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| Verf.angabe: | Christoph Elsing, Christina Herrmann, Carla Verena Hannig, Wolfgang Stremmel, Dirk Jäger, Thomas Herrmann |
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| E-Jahr: | 2013 |
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| Jahr: | October 29, 2013 |
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| Umfang: | 7 S. |
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| Teil: | volume:85 |
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| | year:2013 |
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| | number:5 |
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| | pages:262-268 |
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| | extent:7 |
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| Fussnoten: | Gesehen am 05.02.2021 |
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| Titel Quelle: | Enthalten in: Oncology |
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| Ort Quelle: | Basel : Karger, 1967 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 85(2013), 5, Seite 262-268 |
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| ISSN Quelle: | 1423-0232 |
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| Abstract: | BACKGROUND: The role of second-line chemotherapy in advanced gastric cancer is not yet fully established. - PATIENTS AND METHODS: We analysed 111 patients with advanced gastric cancer treated at the University Hospital Heidelberg (51) and the private oncology practice Bottrop/Dorsten (60) between 2001 and 2011, comparing the outcome of patients with first-line chemotherapy and those who received second-line chemotherapy. - RESULTS: Thirty-six patients were treated with one chemotherapy regimen, 75 patients received at least two different chemotherapies. Patients who received one chemotherapy regimen were older (median age 69 years) and had a shorter overall survival (6 months) than patients receiving sequential chemotherapies [median age 61 years, p = 0.009, overall survival 14 months (2-42), p = 0.001]. Under second-line chemotherapy, partial response was observed in 25 patients (33%) and stable disease for ≥3 months in 26 patients (35%). Patients treated before 2005 had a slightly better overall survival than patients treated in or after 2005. Survival was not influenced by the treatment centre (primary or tertiary), but was influenced by former surgery. - CONCLUSION: The prognosis of advanced gastric cancer is still poor. Selected patients may benefit from individualized salvage chemotherapy after failure of first-line chemotherapy. |
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| DOI: | doi:10.1159/000355690 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000355690 |
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| | DOI: https://doi.org/10.1159/000355690 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aged |
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| | Aged, 80 and over |
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| | Antineoplastic Combined Chemotherapy Protocols |
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| | Camptothecin |
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| | Cisplatin |
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| | Deoxycytidine |
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| | Docetaxel |
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| | Drug Administration Schedule |
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| | Epirubicin |
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| | Etoposide |
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| | Female |
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| | Fluorouracil |
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| | Germany |
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| | Hospitals, University |
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| | Humans |
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| | Irinotecan |
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| | Kaplan-Meier Estimate |
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| | Leucovorin |
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| | Male |
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| | Middle Aged |
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| | Organoplatinum Compounds |
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| | Oxaliplatin |
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| | Paclitaxel |
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| | Prognosis |
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| | Retrospective Studies |
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| | Salvage Therapy |
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| | Stomach Neoplasms |
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| | Taxoids |
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| | Treatment Outcome |
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| K10plus-PPN: | 1747461172 |
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| Verknüpfungen: | → Zeitschrift |
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Sequential chemotherapies for advanced gastric cancer / Elsing, Christoph [VerfasserIn]; October 29, 2013 (Online-Ressource)
68693947
