| |  Online-Ressource |
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| Verfasst von: | Weber, Rebekka [VerfasserIn]  |
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| | Groth, Christopher [VerfasserIn] |
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| | Lasser, Samantha [VerfasserIn] |
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| | Arkhypov, Ihor [VerfasserIn] |
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| | Petrova, Vera [VerfasserIn] |
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| | Altevogt, Peter [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| Titel: | IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy |
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| Verf.angabe: | Rebekka Weber, Christopher Groth, Samantha Lasser, Ihor Arkhypov, Vera Petrova, Peter Altevogt, Jochen Utikal, Viktor Umansky |
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| E-Jahr: | 2021 |
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| Jahr: | January 2021 |
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| Umfang: | 8 S. |
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| Fussnoten: | Available online 29 November 2020 ; Gesehen am 08.02.2021 |
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| Titel Quelle: | Enthalten in: Cellular immunology |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1970 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 359(2021), Artikel-ID 104254, Seite 1-8 |
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| ISSN Quelle: | 1090-2163 |
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| Abstract: | Myeloid-derived suppressor cells (MDSC) are generated during tumor progression and suppress the anti-tumor functions of T and natural killer (NK) cells. Their enrichment is associated with a bad prognosis and a worse outcome of immunotherapy in cancer patients. The cytokine interleukin (IL)-6 was found to be a crucial regulator of MDSC accumulation and activation as well as a factor, stimulating tumor cell proliferation, survival, invasiveness and metastasis. Accordingly, IL-6 can serve as a negative prognostic marker in cancer. On the other hand, this cytokine is also involved in T cell activation. This review discusses the pleiotropic effects of IL-6 on immune cell populations that are critical for tumor development, such as MDSC and T cells, and summarizes the data on targeting IL-6 or IL-6 receptor (IL-6R) for tumor immunotherapy to block MDSC-mediated immunosuppression in cancer patients. |
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| DOI: | doi:10.1016/j.cellimm.2020.104254 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cellimm.2020.104254 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0008874920304147 |
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| | DOI: https://doi.org/10.1016/j.cellimm.2020.104254 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer |
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| | IL-6 |
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| | Immunosuppression |
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| | Immunotherapy |
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| | Myeloid-derived suppressor cells |
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| K10plus-PPN: | 1747714178 |
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| Verknüpfungen: | → Zeitschrift |
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IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy / Weber, Rebekka [VerfasserIn]; January 2021 (Online-Ressource)
