| |  Online-Ressource |
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| Verfasst von: | Mayer, Philipp [VerfasserIn]  |
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| | Kraft, Anne [VerfasserIn] |
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| | Witzel, Hagen R. [VerfasserIn] |
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| | Marnet, Nicole [VerfasserIn] |
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| | Hörner, Nina [VerfasserIn] |
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| | Roth, Wilfried [VerfasserIn] |
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| | Heinrich, Stefan [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Bergmann, Frank [VerfasserIn] |
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| | Kauczor, Hans-Ulrich [VerfasserIn] |
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| | Klauß, Miriam [VerfasserIn] |
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| | Gaida, Matthias M. [VerfasserIn] |
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| Titel: | Restricted water diffusion in diffusion-weighted magnetic resonance imaging in pancreatic cancer is associated with tumor hypoxia |
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| Verf.angabe: | Philipp Mayer, Anne Kraft, Hagen R. Witzel, Nicole Marnet, Nina Hörner, Wilfried Roth, Stefan Heinrich, Thilo Hackert, Frank Bergmann, Hans-Ulrich Kauczor, Miriam Klauss and Matthias M. Gaida |
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| Jahr: | 2021 |
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| Umfang: | 16 S. |
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| Fussnoten: | Published: 30 December 2020 ; Gesehen am 08.02.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 1, Artikel-ID 89, Seite 1-16 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Hypoxia is a hallmark of pancreatic cancer (PDAC) due to its compact and extensive fibrotic tumor stroma. Hypoxia contributes to high lethality of this disease, by inducing a more malignant phenotype and resistance to radiation and chemotherapy. Thus, non-invasive methods to quantify hypoxia could be helpful for treatment decisions, for monitoring, especially in non-resectable tumors, or to optimize personalized therapy. In the present study, we investigated whether tumor hypoxia in PDAC is reflected by diffusion-weighted magnetic resonance imaging (DW-MRI), a functional imaging technique, frequently used in clinical practice for identification and characterization of pancreatic lesions. DW-MRI assesses the tissue microarchitecture by measuring the diffusion of water molecules, which is more restricted in highly compact tissues. As reliable surrogate markers for hypoxia, we determined Blimp-1 (B-lymphocyte induced maturation protein), a transcription factor, as well as vascular endothelial growth factor (VEGF), which are up-regulated in response to hypoxia. In 42 PDAC patients, we observed a close association between restricted water diffusion in DW-MRI and tumor hypoxia in matched samples, as expressed by high levels of Blimp-1 and VEGF in tissue samples of the respective patients. In summary, our data show that DW-MRI is well suited for the evaluation of tumor hypoxia in PDAC and could potentially be used for the identification of lesions with a high hypoxic fraction, which are at high risk for failure of radiochemotherapy. |
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| DOI: | doi:10.3390/cancers13010089 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers13010089 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/1/89 |
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| | DOI: https://doi.org/10.3390/cancers13010089 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | diffusion-weighted imaging |
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| | hypoxia |
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| | pancreatic ductal adenocarcinoma |
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| K10plus-PPN: | 1747724955 |
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| Verknüpfungen: | → Zeitschrift |
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Restricted water diffusion in diffusion-weighted magnetic resonance imaging in pancreatic cancer is associated with tumor hypoxia / Mayer, Philipp [VerfasserIn]; 2021 (Online-Ressource)
