| |  Online-Ressource |
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| Verfasst von: | Schubert, Maria-Luisa [VerfasserIn]  |
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| | Schmitt, Michael [VerfasserIn] |
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| | Wang, Lei [VerfasserIn] |
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| | Ramos, C. A. [VerfasserIn] |
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| | Jordan, Karin [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| Titel: | Side-effect management of chimeric antigen receptor (CAR) T-cell therapy |
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| Verf.angabe: | M. -L. Schubert, M. Schmitt, L. Wang, C.A. Ramos, K. Jordan, C. Müller-Tidow & P. Dreger |
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| Jahr: | 2021 |
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| Umfang: | 15 S. |
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| Fussnoten: | Available online: 21 October 2020 ; Gesehen am 08.02.2021 |
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| Titel Quelle: | Enthalten in: Annals of oncology |
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| Ort Quelle: | Amsterdam [u.a. : Elsevier, 1990 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 32(2021), 1, Seite 34-48 |
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| ISSN Quelle: | 1569-8041 |
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| Abstract: | Chimeric antigen receptor (CAR) T cells directed against the B-cell marker CD19 are currently changing the landscape for treatment of patients with refractory and/or relapsed B-cell malignancies. Due to the nature of CAR T cells as living drugs, they display a unique toxicity profile. As CAR T-cell therapy is extending towards other diseases and being more broadly employed in hematology and oncology, optimal management strategies of side-effects associated with CAR T-cell therapy are of high relevance. Cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and cytopenias constitute challenges in the treatment of patients with CAR T cells. This review summarizes the current understanding of CAR T-cell toxicity and its management. |
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| DOI: | doi:10.1016/j.annonc.2020.10.478 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.annonc.2020.10.478 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0923753420429801 |
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| | DOI: https://doi.org/10.1016/j.annonc.2020.10.478 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CAR T-cell associated side-effects |
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| | CAR T-cell side-effect management |
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| | Chimeric antigen receptor (CAR) T cells |
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| | cytokine release syndrome (CRS) |
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| | immune effector cell-associated neurotoxicity syndrome (ICANS) |
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| K10plus-PPN: | 174774168X |
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| Verknüpfungen: | → Zeitschrift |
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Side-effect management of chimeric antigen receptor (CAR) T-cell therapy / Schubert, Maria-Luisa [VerfasserIn]; 2021 (Online-Ressource)
