Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Hehner, Steffen Peter [VerfasserIn]  |
| Hofmann, Thomas G. [VerfasserIn]  |
| Dröge, Wulf [VerfasserIn]  |
Titel: | Inhibition of tyrosine phosphatases induces apoptosis independent from the CD95 system |
Verf.angabe: | Steffen P. Hehner, Thomas G. Hofmann, Wulf Dröge and M. Lienhard Schmitz |
E-Jahr: | 1999 |
Jahr: | 29 September 1999 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 09.02.2021 |
Titel Quelle: | Enthalten in: Cell death and differentiation |
Ort Quelle: | Houndmills, Basingstoke : Nature Publishing Group, 1997 |
Jahr Quelle: | 1999 |
Band/Heft Quelle: | 6(1999), 9, Seite 833-841 |
ISSN Quelle: | 1476-5403 |
Abstract: | The inhibition of protein tyrosine phosphatases by pervanadate, a potent activator of B- and T-cells through the induction of tyrosine phosphorylation and downstream signaling events in different activation cascades, efficiently induced apoptosis in lymphoid cell lines. Pervanadate-elicited apoptosis could be blocked by the tyrosine kinase inhibitor herbimycin A. This apoptotic process involved the activation of caspases 3, 8 and 9, the induction of mitochondrial permeability transition, the release of cytochrome C and the fragmentation of chromosomal DNA. T-cells lacking the CD95 receptor or caspase-8 and T-cells stably overexpressing a transdominant negative form of the adaptor protein FADD were still susceptible to pervanadate-induced apoptosis, excluding the involvement of the CD95 system or other FADD-dependent death receptors. The apoptotic program initiated by the inhibition of tyrosine phosphatases did not require the presence of the tyrosine kinase p56lck or phosphatase CD45, whereas Bcl-2 overexpression protected T-cells from pervanadate-induced cytochrome C release, caspase-8 cleavage and apoptosis. |
DOI: | doi:10.1038/sj.cdd.4400559 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.cdd.4400559 |
| Volltext: https://www.nature.com/articles/4400559 |
| DOI: https://doi.org/10.1038/sj.cdd.4400559 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1747806617 |
Verknüpfungen: | → Zeitschrift |
Inhibition of tyrosine phosphatases induces apoptosis independent from the CD95 system / Hehner, Steffen Peter [VerfasserIn]; 29 September 1999 (Online-Ressource)
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