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Verfasst von:Paschen, Annette [VerfasserIn]   i
 Song, Mingxia [VerfasserIn]   i
 Nguyen, Xuan-Duc [VerfasserIn]   i
 Osen, Wolfram [VerfasserIn]   i
 Schadendorf, Dirk [VerfasserIn]   i
 Geginat, Gernot [VerfasserIn]   i
Titel:Identification of a cross-reactive HLA-DRB1*0301-restricted CD4 T cell response directed against cholesterol-binding cytolysins from two different pathogens
Verf.angabe:Annette Paschen, Mingxia Song, Simone Schenk, Jozef Janda, Xuan Duc Nguyen, Wolfram Osen, Dirk Schadendorf, Gernot Geginat
E-Jahr:2006
Jahr:30 May 2006
Umfang:10 S.
Fussnoten:Gesehen am 09.02.2021
Titel Quelle:Enthalten in: Microbes and infection
Ort Quelle:Paris [u.a.] : Elsevier, 1999
Jahr Quelle:2006
Band/Heft Quelle:8(2006), 8, Seite 2034-2043
ISSN Quelle:1769-714X
Abstract:Cholesterol-binding cytolysins constitute an evolutionarily conserved family of pore-forming proteins expressed by different Gram-positive pathogens. Listeriolysin O, one well-characterized member of the cytolysin family, is also known to induce specific CD4 and CD8 T cell responses upon infection of mice with Listeria monocytogenes. Here we describe an HLA-DRB1*0301-restricted listeriolysin O-derived T cell epitope that is conserved among several members of the cytolysin family. An HLA-DRB1*0301-restricted CD4+T cell line, established from spleen lymphocytes of L. monocytogenes-infected HLA-DRB1*0301-transgenic mice, cross-reacted with a homologous peptide from perfringolysin O, a cytolysin expressed by Clostridium perfringens. Ex vivo analysis of infected mice revealed an even broader cross-reaction of T cells with homologous peptides derived from perfringolysin O, streptolysin O, and cereolysin O. Interestingly, a cross-reactive memory CD4+T cell response against the homologous peptides derived from listeriolysin O and perfringolysin O could also be detected in the blood from healthy HLA-DRB1*0301+ human donors. Remarkably, this response was even present in donors who did not exhibit a memory T cell reactivity against a second, non-conserved HLA-DRB1*0301-restricted LLO-derived CD4 T cell epitope, suggesting that cytolysin-producing bacteria other than L. monocytogenes can stimulate a cross-reactive cytolysin-specific immunity.
DOI:doi:10.1016/j.micinf.2006.03.010
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.micinf.2006.03.010
 Volltext: https://www.sciencedirect.com/science/article/pii/S1286457906001626
 DOI: https://doi.org/10.1016/j.micinf.2006.03.010
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Bacterial infection
 Immune responses
 T helper cells
K10plus-PPN:1747884057
Verknüpfungen:→ Zeitschrift

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