| Online-Ressource |
Verfasst von: | Paschen, Annette [VerfasserIn]  |
| Song, Mingxia [VerfasserIn]  |
| Nguyen, Xuan-Duc [VerfasserIn]  |
| Osen, Wolfram [VerfasserIn]  |
| Schadendorf, Dirk [VerfasserIn]  |
| Geginat, Gernot [VerfasserIn]  |
Titel: | Identification of a cross-reactive HLA-DRB1*0301-restricted CD4 T cell response directed against cholesterol-binding cytolysins from two different pathogens |
Verf.angabe: | Annette Paschen, Mingxia Song, Simone Schenk, Jozef Janda, Xuan Duc Nguyen, Wolfram Osen, Dirk Schadendorf, Gernot Geginat |
E-Jahr: | 2006 |
Jahr: | 30 May 2006 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 09.02.2021 |
Titel Quelle: | Enthalten in: Microbes and infection |
Ort Quelle: | Paris [u.a.] : Elsevier, 1999 |
Jahr Quelle: | 2006 |
Band/Heft Quelle: | 8(2006), 8, Seite 2034-2043 |
ISSN Quelle: | 1769-714X |
Abstract: | Cholesterol-binding cytolysins constitute an evolutionarily conserved family of pore-forming proteins expressed by different Gram-positive pathogens. Listeriolysin O, one well-characterized member of the cytolysin family, is also known to induce specific CD4 and CD8 T cell responses upon infection of mice with Listeria monocytogenes. Here we describe an HLA-DRB1*0301-restricted listeriolysin O-derived T cell epitope that is conserved among several members of the cytolysin family. An HLA-DRB1*0301-restricted CD4+T cell line, established from spleen lymphocytes of L. monocytogenes-infected HLA-DRB1*0301-transgenic mice, cross-reacted with a homologous peptide from perfringolysin O, a cytolysin expressed by Clostridium perfringens. Ex vivo analysis of infected mice revealed an even broader cross-reaction of T cells with homologous peptides derived from perfringolysin O, streptolysin O, and cereolysin O. Interestingly, a cross-reactive memory CD4+T cell response against the homologous peptides derived from listeriolysin O and perfringolysin O could also be detected in the blood from healthy HLA-DRB1*0301+ human donors. Remarkably, this response was even present in donors who did not exhibit a memory T cell reactivity against a second, non-conserved HLA-DRB1*0301-restricted LLO-derived CD4 T cell epitope, suggesting that cytolysin-producing bacteria other than L. monocytogenes can stimulate a cross-reactive cytolysin-specific immunity. |
DOI: | doi:10.1016/j.micinf.2006.03.010 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.micinf.2006.03.010 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S1286457906001626 |
| DOI: https://doi.org/10.1016/j.micinf.2006.03.010 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Bacterial infection |
| Immune responses |
| T helper cells |
K10plus-PPN: | 1747884057 |
Verknüpfungen: | → Zeitschrift |
Identification of a cross-reactive HLA-DRB1*0301-restricted CD4 T cell response directed against cholesterol-binding cytolysins from two different pathogens / Paschen, Annette [VerfasserIn]; 30 May 2006 (Online-Ressource)