Melanoma-reactive T cells in the bone marrow of melanoma patients

• Verfasst von: Müller-Berghaus, Jan [VerfasserIn]
• Verfasst von: Ugurel, Selma [VerfasserIn]
• Verfasst von: Umansky, Viktor [VerfasserIn]
• Verfasst von: Schirrmacher, Volker [VerfasserIn]
• Verfasst von: Beckhove, Philipp [VerfasserIn]
• Verfasst von: Schadendorf, Dirk [VerfasserIn]
• Titel: Melanoma-reactive T cells in the bone marrow of melanoma patients
• Titelzusatz: association with disease stage and disease duration
• Verf.angabe: Jan Müller-Berghaus, Katrin Ehlert, Selma Ugurel, Viktor Umansky, Mariana Bucur, Volker Schirrmacher, Philipp Beckhove, and Dirk Schadendorf
• E-Jahr: 2006
• Jahr: June 15, 2006
• Umfang: 5 S.
• Fussnoten: Gesehen am 09.02.2021
• Titel Quelle: Enthalten in: Cancer research
• Ort Quelle: Philadelphia, Pa. : AACR, 1916
• Jahr Quelle: 2006
• Band/Heft Quelle: 66(2006), 12, Seite 5997-6001
• ISSN Quelle: 1538-7445
• DOI: doi:10.1158/0008-5472.CAN-04-0484
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1747884766

Abstract

Using IFN-γ enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients.