Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats

• Verfasst von: Koch, Martin Jean [VerfasserIn]
• Verfasst von: Biesalski, Hans-Konrad [VerfasserIn]
• Verfasst von: Stofft, Eckart [VerfasserIn]
• Verfasst von: Weiser, Harald [VerfasserIn]
• Verfasst von: Gabbert, Helmut E. [VerfasserIn]
• Verfasst von: Dienes, Hans-P. [VerfasserIn]
• Verfasst von: Schulz-Dobrick, Burkard [VerfasserIn]
• Verfasst von: Bässler, Karl H. [VerfasserIn]
• Titel: Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats
• Verf.angabe: Martin J. Koch, Hans K. Biesalski, Eckart Stofft, Harald Weiser, Helmut E. Gabbert, Hans-P. Dienes, Burkard Schulz-Dobrick, and Karl H. Bässler
• E-Jahr: 1990
• Jahr: January 1990
• Umfang: 4 S.
• Fussnoten: Gesehen am 10.02.2021
• Titel Quelle: Enthalten in: Cell & tissue research
• Ort Quelle: Berlin : Springer, 1924
• Jahr Quelle: 1990
• Band/Heft Quelle: 260(1990), 3, Seite 625-628
• ISSN Quelle: 1432-0878
• DOI: doi:10.1007/BF00297244
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1748015915

Abstract

The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.