Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker

• Verfasst von: Heller, Raban [VerfasserIn]
• Verfasst von: Sun, Qian [VerfasserIn]
• Verfasst von: Hackler, Julian [VerfasserIn]
• Verfasst von: Seelig, Julian [VerfasserIn]
• Verfasst von: Seibert, Linda [VerfasserIn]
• Verfasst von: Cherkezov, Asan [VerfasserIn]
• Verfasst von: Minich, Waldemar B. [VerfasserIn]
• Verfasst von: Seemann, Petra [VerfasserIn]
• Verfasst von: Diegmann, Joachim [VerfasserIn]
• Verfasst von: Pilz, Maximilian [VerfasserIn]
• Verfasst von: Bachmann, Manuel [VerfasserIn]
• Verfasst von: Ranjbar, Alireza [VerfasserIn]
• Verfasst von: Moghaddam-Alvandi, Arash [VerfasserIn]
• Verfasst von: Schomburg, Lutz [VerfasserIn]
• Titel: Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker
• Verf.angabe: Raban Arved Heller, Qian Sun, Julian Hackler, Julian Seelig, Linda Seibert, Asan Cherkezov, Waldemar B. Minich, Petra Seemann, Joachim Diegmann, Maximilian Pilz, Manuel Bachmann, Alireza Ranjbar, Arash Moghaddam, Lutz Schomburg
• Jahr: 2021
• Umfang: 9 S.
• Fussnoten: Available online 20 October 2020 ; Gesehen am 11.02.2021
• Titel Quelle: Enthalten in: Redox Biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2013
• Jahr Quelle: 2021
• Band/Heft Quelle: 38(2021) Artikel-Nummer 101764, 9 Seiten
• ISSN Quelle: 2213-2317
• DOI: doi:10.1016/j.redox.2020.101764
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarker
• Sach-SW: COVID-19
• Sach-SW: Inflammation
• Sach-SW: Micronutrient
• Sach-SW: Trace element
• K10plus-PPN: 1748067575

Abstract

SARS-CoV-2 infections cause the current coronavirus disease (COVID-19) pandemic and challenge the immune system with ongoing inflammation. Several redox-relevant micronutrients are known to contribute to an adequate immune response, including the essential trace elements zinc (Zn) and selenium (Se). In this study, we tested the hypothesis that COVID-19 patients are characterised by Zn deficiency and that Zn status provides prognostic information. Serum Zn was determined in serum samples (n = 171) collected consecutively from patients surviving COVID-19 (n = 29) or non-survivors (n = 6). Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study were used for comparison. Zn concentrations in patient samples were low as compared to healthy subjects (mean ± SD; 717.4 ± 246.2 vs 975.7 ± 294.0 μg/L, P < 0.0001). The majority of serum samples collected at different time points from the non-survivors (25/34, i.e., 73.5%) and almost half of the samples collected from the survivors (56/137, i.e., 40.9%) were below the threshold for Zn deficiency, i.e., below 638.7 μg/L (the 2.5th percentile in the EPIC cohort). In view that the Se status biomarker and Se transporter selenoprotein P (SELENOP) is also particularly low in COVID-19, we tested the prevalence of a combined deficit, i.e., serum Zn below 638.7 μg/L and serum SELENOP below 2.56 mg/L. This combined deficit was observed in 0.15% of samples in the EPIC cohort of healthy subjects, in 19.7% of the samples collected from the surviving COVID-19 patients and in 50.0% of samples from the non-survivors. Accordingly, the composite biomarker (SELENOP and Zn with age) proved as a reliable indicator of survival in COVID-19 by receiver operating characteristic (ROC) curve analysis, yielding an area under the curve (AUC) of 94.42%. We conclude that Zn and SELENOP status within the reference ranges indicate high survival odds in COVID-19, and assume that correcting a diagnostically proven deficit in Se and/or Zn by a personalised supplementation may support convalescence.