| |  Online-Ressource |
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| Verfasst von: | Beed, Prateep Sanker [VerfasserIn]  |
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| | Filippo, Roberto De [VerfasserIn] |
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| | Holman, Constance [VerfasserIn] |
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| | Johenning, Friedrich W. [VerfasserIn] |
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| | Leibold, Christian [VerfasserIn] |
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| | Caputi, Antonio [VerfasserIn] |
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| | Monyer, Hannah [VerfasserIn] |
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| | Schmitz, Dietmar [VerfasserIn] |
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| Titel: | Layer 3 pyramidal cells in the medial entorhinal cortex orchestrate up-down states and entrain the deep layers differentially |
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| Verf.angabe: | Prateep Beed, Roberto de Filippo, Constance Holman, Friedrich W. Johenning, Christian Leibold, Antonio Caputi, Hannah Monyer, and Dietmar Schmitz |
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| E-Jahr: | 2020 |
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| Jahr: | December 8, 2020 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 11.02.2021 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 33(2020,10) Artikel-Nummer 108470, 16 Seiten |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Up-down states (UDS) are synchronous cortical events of neuronal activity during non-REM sleep. The medial entorhinal cortex (MEC) exhibits robust UDS during natural sleep and under anesthesia. However, little is known about the generation and propagation of UDS-related activity in the MEC. Here, we dissect the circuitry underlying UDS generation and propagation across layers in the MEC using both in vivo and in vitro approaches. We provide evidence that layer 3 (L3) MEC is crucial in the generation and maintenance of UDS in the MEC. Furthermore, we find that the two sublayers of the L5 MEC participate differentially during UDS. Our findings show that L5b, which receives hippocampal output, is strongly innervated by UDS activity originating in L3 MEC. Our data suggest that L5b acts as a coincidence detector during information transfer between the hippocampus and the cortex and thereby plays an important role in memory encoding and consolidation. |
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| DOI: | doi:10.1016/j.celrep.2020.108470 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2020.108470 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124720314595 |
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| | DOI: https://doi.org/10.1016/j.celrep.2020.108470 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | entorhinal cortex |
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| | layer 3 |
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| | layer 5 |
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| | Oxr1 |
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| | up-down states |
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| K10plus-PPN: | 1748082663 |
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| Verknüpfungen: | → Zeitschrift |
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Layer 3 pyramidal cells in the medial entorhinal cortex orchestrate up-down states and entrain the deep layers differentially / Beed, Prateep Sanker [VerfasserIn]; December 8, 2020 (Online-Ressource)
