| |  Online-Ressource |
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| Verfasst von: | Wilhelm, Theresa Rita [VerfasserIn]  |
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| | Taddeo, Adriano [VerfasserIn] |
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| | Winter, Oliver [VerfasserIn] |
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| | Schulz, Axel Ronald [VerfasserIn] |
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| | Mälzer, Julia-Nora [VerfasserIn] |
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| | Domingo, Cristina [VerfasserIn] |
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| | Biesen, Robert [VerfasserIn] |
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| | Alexander, Tobias [VerfasserIn] |
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| | Thiel, Andreas [VerfasserIn] |
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| | Radbruch, Andreas [VerfasserIn] |
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| | Hiepe, Falk [VerfasserIn] |
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| | Gerl, Velia [VerfasserIn] |
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| Titel: | Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood |
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| Titelzusatz: | a semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses |
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| Verf.angabe: | Theresa R. Wilhelm, Adriano Taddeo, Oliver Winter, Axel Ronald Schulz, Julia-Nora Mälzer, Cristina Domingo, Robert Biesen, Tobias Alexander, Andreas Thiel, Andreas Radbruch, Falk Hiepe, Velia Gerl |
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| Jahr: | 2016 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 10 S. |
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| Fussnoten: | Available online 7 December 2015 ; Gesehen am 11.02.2021 |
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| Titel Quelle: | Enthalten in: Clinical immunology |
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| Ort Quelle: | San Diego, Calif. : Elsevier, 1999 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 163(2016), Seite 42-51 |
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| ISSN Quelle: | 1521-7035 |
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| Abstract: | Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN-α producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation of adaptive immunoresponses, is expressed in a subset of semi-mature, myeloid-like pDCs in human blood. These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN-α via TLR7/TLR9 engagement. In vitro, Siglec-1 expression was induced in Siglec-1-negative pDCs by influenza virus. Proportions of Siglec-1-positive/Siglec-1-negative pDCs were higher in SLE than in healthy controls and correlated with disease activity. Healthy donors immunized with yellow fever vaccine YFV-17D displayed different kinetics of the two pDC subsets during protective immune response. PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses. |
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| DOI: | doi:10.1016/j.clim.2015.12.001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.clim.2015.12.001 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S152166161530070X |
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| | DOI: https://doi.org/10.1016/j.clim.2015.12.001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Erythematosus |
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| | Plasmacytoide dendritic cell |
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| | Siglec-1 |
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| | Systemic lupus |
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| K10plus-PPN: | 1748085921 |
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| Verknüpfungen: | → Zeitschrift |
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Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood / Wilhelm, Theresa Rita [VerfasserIn]; 2016 (Online-Ressource)
