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Verfasst von:Vajda, Flóra [VerfasserIn]   i
 Jordi, N. [VerfasserIn]   i
 Dalkara, D. [VerfasserIn]   i
 Joly, S. [VerfasserIn]   i
 Christ, F. [VerfasserIn]   i
 Tews, Björn [VerfasserIn]   i
 Schwab, M. E. [VerfasserIn]   i
 Pernet, V. [VerfasserIn]   i
Titel:Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve
Verf.angabe:F. Vajda, N. Jordi, D. Dalkara, S. Joly, F. Christ, B. Tews, M.E. Schwab and V. Pernet
Jahr:2015
Jahr des Originals:2014
Umfang:13 S.
Fussnoten:published online 26 September 2014 ; Gesehen am 12.02.2021
Titel Quelle:Enthalten in: Cell death and differentiation
Ort Quelle:Houndmills, Basingstoke : Nature Publishing Group, 1997
Jahr Quelle:2015
Band/Heft Quelle:22(2015), 2, Seite 323-335
ISSN Quelle:1476-5403
Abstract:Nogo-A is a well-known myelin-enriched inhibitory protein for axonal growth and regeneration in the central nervous system (CNS). Besides oligodendrocytes, our previous data revealed that Nogo-A is also expressed in subpopulations of neurons including retinal ganglion cells, in which it can have a positive role in the neuronal growth response after injury, through an unclear mechanism. In the present study, we analyzed the opposite roles of glial versus neuronal Nogo-A in the injured visual system. To this aim, we created oligodendrocyte (Cnp-Cre+/−xRtn4/Nogo-Aflox/flox) and neuron-specific (Thy1-Cretg+xRtn4flox/flox) conditional Nogo-A knock-out (KO) mouse lines. Following complete intraorbital optic nerve crush, both spontaneous and inflammation-mediated axonal outgrowth was increased in the optic nerves of the glia-specific Nogo-A KO mice. In contrast, neuron-specific deletion of Nogo-A in a KO mouse line or after acute gene recombination in retinal ganglion cells mediated by adeno-associated virus serotype 2.Cre virus injection in Rtn4flox/flox animals decreased axon sprouting in the injured optic nerve. These results therefore show that selective ablation of Nogo-A in oligodendrocytes and myelin in the optic nerve is more effective at enhancing regrowth of injured axons than what has previously been observed in conventional, complete Nogo-A KO mice. Our data also suggest that neuronal Nogo-A in retinal ganglion cells could participate in enhancing axonal sprouting, possibly by cis-interaction with Nogo receptors at the cell membrane that may counteract trans-Nogo-A signaling. We propose that inactivating Nogo-A in glia while preserving neuronal Nogo-A expression may be a successful strategy to promote axonal regeneration in the CNS.
DOI:doi:10.1038/cdd.2014.147
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1038/cdd.2014.147
 Volltext: https://www.nature.com/articles/cdd2014147
 DOI: https://doi.org/10.1038/cdd.2014.147
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1748199080
Verknüpfungen:→ Zeitschrift

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