Status: Bibliographieeintrag
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| Verfasst von: | Deleu, Laurent [VerfasserIn]  |
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| | Nüesch, Jürg P. F. [VerfasserIn] |
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| | Rommelaere, Jean [VerfasserIn] |
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| Titel: | Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 |
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| Verf.angabe: | Laurent Deleu, Aurora Pujol, Jürg P.F. Nüesch and Jean Rommelaere |
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| E-Jahr: | 2001 |
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| Jahr: | 01 August 2001 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 15.02.2021 |
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| Titel Quelle: | Enthalten in: Journal of general virology |
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| Ort Quelle: | Reading : Soc., 1967 |
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| Jahr Quelle: | 2001 |
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| Band/Heft Quelle: | 82(2001), 8, Seite 1929-1934 |
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| ISSN Quelle: | 1465-2099 |
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| Abstract: | Nonstructural protein 1 (NS1) of minute virus of mice is involved in viral DNA replication, transcriptional regulation and cytotoxic action in the host cell. Viral DNA replication is dependent on the ability of NS1 to form homo-oligomers. To investigate whether oligomerization is required for NS1 transcriptional activities, a functionally impaired mutant derivative of NS1 that was able to interact with the wild-type (wt) protein and inhibit its activity in a dominant-negative manner was designed. This mutant provided evidence that transactivation of the parvoviral P38 promoter and transinhibition of a heterologous promoter by NS1 were both affected by the co-expression of the wt and the dominant-negative mutant form of NS1. These results indicate that additional functions of NS1, involved in promoter regulation, require oligomer formation., |
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| DOI: | doi:10.1099/0022-1317-82-8-1929 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1099/0022-1317-82-8-1929 |
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| | Volltext: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-8-1929 |
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| | DOI: https://doi.org/10.1099/0022-1317-82-8-1929 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1748302892 |
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| Verknüpfungen: | → Zeitschrift |
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Inhibition of transcription-regulating properties of nonstructural protein 1 (NS1) of parvovirus minute virus of mice by a dominant-negative mutant form of NS1 / Deleu, Laurent [VerfasserIn]; 01 August 2001 (Online-Ressource)
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