| |  Online-Ressource |
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| Verfasst von: | Penno, Carlos A. [VerfasserIn]  |
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| | Morgan, Stuart A. [VerfasserIn] |
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| | Rose, Adam J. [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| | Lavery, Gareth G. [VerfasserIn] |
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| | Odermatt, Alex [VerfasserIn] |
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| Titel: | 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice |
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| Verf.angabe: | Carlos A. Penno, Stuart A. Morgan, Adam J. Rose, Stephan Herzig, Gareth G. Lavery, Alex Odermatt |
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| E-Jahr: | 2014 |
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| Jahr: | 2 May 2014 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 16.02.2021 |
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| Titel Quelle: | Enthalten in: Molecular metabolism |
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| Ort Quelle: | Oxford [u.a.] : Elsevier, 2012 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 3(2014), 5, Seite 554-564 |
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| ISSN Quelle: | 2212-8778 |
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| Abstract: | 11β-Hydroxysteroid dehydrogenase-1 (11β-HSD1) plays a key role in glucocorticoid receptor (GR) activation. Besides, it metabolizes some oxysterols and bile acids (BAs). The GR regulates BA homeostasis; however, the impact of impaired 11β-HSD1 activity remained unknown. We profiled plasma and liver BAs in liver-specific and global 11β-HSD1-deficient mice. 11β-HSD1-deficiency resulted in elevated circulating unconjugated BAs, an effect more pronounced in global than liver-specific knockout mice. Gene expression analyses revealed decreased expression of the BA-CoA ligase Fatp5, suggesting impaired BA amidation. Reduced organic anion-transporting polypeptide-1A1 (Oatp1a1) and enhanced organic solute-transporter-β (Ostb) mRNA expression were observed in livers from global 11β-HSD1-deficient mice. The impact of 11β-HSD1-deficiency on BA homeostasis seems to be GR-independent because intrahepatic corticosterone and GR target gene expression were not substantially decreased in livers from global knockout mice. Moreover, Fatp5 expression in livers from hepatocyte-specific GR knockout mice was unchanged. The results revealed a role for 11β-HSD1 in BA homeostasis. |
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| DOI: | doi:10.1016/j.molmet.2014.04.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.molmet.2014.04.008 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2212877814000866 |
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| | DOI: https://doi.org/10.1016/j.molmet.2014.04.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 11β-Hydroxysteroid dehydrogenase |
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| | Bile acid conjugation |
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| | Bile acid transport |
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| | Bile acids |
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| | Glucocorticoids |
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| K10plus-PPN: | 1748461257 |
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| Verknüpfungen: | → Zeitschrift |
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11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice / Penno, Carlos A. [VerfasserIn]; 2 May 2014 (Online-Ressource)
