BOLD-MRI in ten patients with coronary artery disease

• Verfasst von: Wacker, Christian [VerfasserIn]
• Verfasst von: Bock, Michael [VerfasserIn]
• Verfasst von: Bauer, Wolfgang Rudolf [VerfasserIn]
• Verfasst von: Kaick, Gerhard van [VerfasserIn]
• Verfasst von: Pfleger, Stefan [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Titel: BOLD-MRI in ten patients with coronary artery disease
• Titelzusatz: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery
• Verf.angabe: Christian M. Wacker, Michael Bock, Andreas W. Hartlep, Wolfgang R. Bauer, Gerhard van Kaick, Stefan Pfleger, Georg Ertl, Lothar R. Schad
• E-Jahr: 1999
• Jahr: March 1999
• Umfang: 7 S.
• Fussnoten: Gesehen am 17.02.2021
• Titel Quelle: Enthalten in: Magnetic resonance materials in physics, biology and medicine
• Ort Quelle: Heidelberg : Springer, 1993
• Jahr Quelle: 1999
• Band/Heft Quelle: 8(1999), Seite 48-54
• ISSN Quelle: 1352-8661
• DOI: doi:10.1007/BF02590635
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 174849161X

Abstract

Changes of myocardial oxygenation can be studied by measurements of the apparent transverse relaxation timeT 2 * , which is correlated with the oxygenation state of hemoglobin. In this study, ten patients with coronary artery disease (CAD) underwent blood oxygenation level dependent (BOLD)T 2 * measurements using a segmented gradient echo pulse sequence with ten echoes.T 2 * measurements were performed in a single short-axis slice of the heart at rest and under pharmacological stress with dipyridamole (DIP), which increases myocardial blood flow. For comparison, all patients underwent X-ray angiography and stress-echocardiography within 4 days after the MR exam. In one patient, MR examination was repeated 10 weeks after percutaneous transluminal coronary angioplasty (PTA). In the differentialT 2 * maps, expected ischemic areas of myocardium were identified in six patients. In these regions,T 2 * values (30±8 ms) were significantly reduced when compared to the remaining myocardium (48±9 ms,P<0.01). In four patients, the myocardial region of interest could not be assessed owing to severe susceptibility artifacts in the ischemic region. The success of the PTA treatment could be visualized from a more homogeneous DIP induced increase inT 2 * within the ischemic myocardium (from 26±1 to 29±1 ms before PTA versus 26±1 to 31±4 ms after PTA,P<0.001.