Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk

• Verfasst von: Ghoneim, Dalia H. [VerfasserIn]
• Verfasst von: Canzian, Federico [VerfasserIn]
• Verfasst von: Hackert, Thilo [VerfasserIn]
• Titel: Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk
• Verf.angabe: Dalia H. Ghoneim, Federico Canzian, Thilo Hackert [und 74 weitere]
• E-Jahr: 2020
• Jahr: September 23, 2020
• Umfang: 5 S.
• Fussnoten: Gesehen am 18.02.2021
• Titel Quelle: Enthalten in: Cancer epidemiology, biomarkers & prevention
• Ort Quelle: Philadelphia, Pa. : AACR, 1991
• Jahr Quelle: 2020
• Band/Heft Quelle: 29(2020), 12, Seite 2735-2739
• ISSN Quelle: 1538-7755
• DOI: doi:10.1158/1055-9965.EPI-20-0651
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1748621904

Abstract

Background: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome. - Methods: We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data. - Results: Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98-1.02; arachidonic acid OR = 1.00, 95% CI = 0.99-1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex. - Conclusions: Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk. - Impact: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer.