| |  Online-Ressource |
|---|
| Verfasst von: | Tirinato, Luca [VerfasserIn]  |
|---|
| | Pagliari, Francesca [VerfasserIn] |
|---|
| | Di Franco, Simone [VerfasserIn] |
|---|
| | Sogne, Elisa [VerfasserIn] |
|---|
| | Marafioti, Maria Grazia [VerfasserIn] |
|---|
| | Jansen, Jeannette [VerfasserIn] |
|---|
| | Falqui, Andrea [VerfasserIn] |
|---|
| | Todaro, Matilde [VerfasserIn] |
|---|
| | Candeloro, Patrizio [VerfasserIn] |
|---|
| | Liberale, Carlo [VerfasserIn] |
|---|
| | Seco, Joao [VerfasserIn] |
|---|
| | Stassi, Giorgio [VerfasserIn] |
|---|
| | Di Fabrizio, Enzo [VerfasserIn] |
|---|
| Titel: | ROS and lipid droplet accumulation induced by high glucose exposure in healthy colon and colorectal cancer stem cells |
|---|
| Verf.angabe: | Luca Tirinato, Francesca Pagliari, Simone Di Franco, Elisa Sogne, Maria Grazia Marafioti, Jeanette Jansen, Andrea Falqui, Matilde Todaro, Patrizio Candeloro, Carlo Liberale, Joao Seco, Giorgio Stassi, Enzo Di Fabrizio |
|---|
| Jahr: | 2020 |
|---|
| Jahr des Originals: | 2019 |
|---|
| Umfang: | 16 S. |
|---|
| Fussnoten: | Gesehen am 19.02.2021 ; Available online 25 September 2019 |
|---|
| Titel Quelle: | Enthalten in: Genes & diseases |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2014 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 7(2020), 4, Seite 620-635 |
|---|
| ISSN Quelle: | 2352-3042 |
|---|
| Abstract: | Lipid Droplets (LDs) are emerging as crucial players in colon cancer development and maintenance. Their expression has been associated with high tumorigenicity in Cancer Stem Cells (CSCs), so that they have been proposed as a new functional marker in Colorectal Cancer Stem Cells (CR-CSCs). They are also indirectly involved in the modulation of the tumor microenvironment through the production of pro-inflammatory molecules. There is growing evidence that a possible connection between metabolic alterations and malignant transformation exists, although the effects of nutrients, primarily glucose, on the CSC behavior are still mostly unexplored. Glucose is an essential fuel for cancer cells, and the connections with LDs in the healthy and CSC populations merit to be more deeply investigated. Here, we showed that a high glucose concentration activated the PI3K/AKT pathway and increased the expression of CD133 and CD44v6 CSC markers. Additionally, glucose was responsible for the increased amount of Reactive Oxygen Species (ROS) and LDs in both healthy and CR-CSC samples. We also investigated the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most affected. Lastly, Atorvastatin, a lipid-lowering drug, induced the highest mortality on CR-CSCs without affecting the healthy counterpart. |
|---|
| DOI: | doi:10.1016/j.gendis.2019.09.010 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.gendis.2019.09.010 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S2352304219300819 |
|---|
| | DOI: https://doi.org/10.1016/j.gendis.2019.09.010 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Cholesterol metabolism |
|---|
| | Colorectal cancer stem cells |
|---|
| | Fatty acid metabolism |
|---|
| | High glucose |
|---|
| | Lipid droplets |
|---|
| | Oncogenes |
|---|
| | Oxidative stress |
|---|
| | PI3K-AKT |
|---|
| K10plus-PPN: | 1748665308 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
ROS and lipid droplet accumulation induced by high glucose exposure in healthy colon and colorectal cancer stem cells / Tirinato, Luca [VerfasserIn]; 2020 (Online-Ressource)
