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Status: Bibliographieeintrag

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Verfasst von:Naujokat, Cord [VerfasserIn]   i
 Šarić, Tomo [VerfasserIn]   i
Titel:Concise review
Titelzusatz:role and function of the ubiquitin-proteasome system in mammalian stem and progenitor cells
Verf.angabe:Cord Naujokat, Tomo Šarić
Jahr:2007
Umfang:11 S.
Fussnoten:Gesehen am 19.02.2021
Titel Quelle:Enthalten in: Stem cells
Ort Quelle:Hoboken, NJ : Wiley-Blackwell, 1983
Jahr Quelle:2007
Band/Heft Quelle:25(2007), 10, Seite 2408-2418
ISSN Quelle:1549-4918
Abstract:Highly ordered degradation of cell proteins by the ubiquitin-proteasome system, a sophisticated cellular proteolytic machinery, has been identified as a key regulatory mechanism in many eukaryotic cells. Accumulating evidence reveals that the ubiquitin-proteasome system is involved in the regulation of fundamental processes in mammalian stem and progenitor cells of embryonic, neural, hematopoietic, and mesenchymal origin. Such processes, including development, survival, differentiation, lineage commitment, migration, and homing, are directly controlled by the ubiquitin-proteasome system, either via proteolytic degradation of key regulatory proteins of signaling and gene expression pathways or via nonproteolytic mechanisms involving the proteasome itself or posttranslational modifications of target proteins by ubiquitin or other ubiquitin-like modifiers. Future characterization of the precise roles and functions of the ubiquitin-proteasome system in mammalian stem and early progenitor cells will improve our understanding of stem cell biology and may provide an experimental basis for the development of novel therapeutic strategies in regenerative medicine. Disclosure of potential conflicts of interest is found at the end of this article.
DOI:doi:10.1634/stemcells.2007-0255
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1634/stemcells.2007-0255
 Volltext: https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1634/stemcells.2007-0255
 DOI: https://doi.org/10.1634/stemcells.2007-0255
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Animals
 Brain
 Embryonic Stem Cells
 Hematopoietic Stem Cells
 Humans
 Intracellular Signaling Peptides and Proteins
 Mammals
 Mesenchymal Stem Cells
 Mice
 Neurons
 Proteasome Endopeptidase Complex
 Proteins
 Stem Cell Transplantation
 Stem Cells
 Ubiquitin
K10plus-PPN:1748689177
Verknüpfungen:→ Zeitschrift

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