Inverse association between IgG-anti-κ and antierythrocyte autoantibodies in patients with cold agglutination

• Verfasst von: Terness, Peter [VerfasserIn]
• Verfasst von: Navolan, Dan Bogdan [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Verfasst von: Roelcke, Dieter [VerfasserIn]
• Titel: Inverse association between IgG-anti-κ and antierythrocyte autoantibodies in patients with cold agglutination
• Verf.angabe: P. Terness, D. Navolan, G. Opelz, D. Roelcke
• Jahr: 1999
• Umfang: 4 S.
• Fussnoten: Gesehen am 19.02.2021
• Titel Quelle: Enthalten in: Blood
• Ort Quelle: Washington, DC : American Society of Hematology, 1946
• Jahr Quelle: 1999
• Band/Heft Quelle: 94(1999), 12, Seite 4343-4346
• ISSN Quelle: 1528-0020
• DOI: doi:10.1182/blood.V94.12.4343
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Anemia, Hemolytic, Autoimmune
• Sach-SW: Antibody Specificity
• Sach-SW: Autoantibodies
• Sach-SW: B-Lymphocytes
• Sach-SW: Erythrocytes
• Sach-SW: Humans
• Sach-SW: Immunoglobulin G
• Sach-SW: Immunoglobulin kappa-Chains
• K10plus-PPN: 1748701061

Abstract

It has been known for a long time that IgG-anti-F(ab')(2) antibodies (Abs) are able to suppress the B-cell response. We showed that natural IgG-anti-F(ab')(2) autoantibodies appear in the serum of patients with cold agglutination. If the anti-F(ab')2 Ab suppresses cold agglutinin (CA)-producing B cells, one would expect an inverse correlation between the titers of these two Abs. Our study confirmed this correlation. Subsequent experiments showed that some anti-F(ab')(2) Abs bind to the hinge region of IgG. It was difficult to explain how this Ab suppresses CA-producing B cells, which are of IgM isotype. Here we show that patients with cold agglutination have an IgG-anti-kappa light chain autoantibody in their serum. This is another member of the anti-F(ab')(2) Ab group. Because the vast majority of CAs are IgM-kappa Abs, the anti-kappa Ab might suppress CA-producing B cells. If this is the case, there should be an inverse association between the titer of anti-kappa Ab and CA. In a group of 302 patients, we found that high titers of the anti-kappa Ab correlate with low titers of CA and vice versa (P =.009). Interestingly, this association is found only in patients whose disease is caused by noninfectious agents, including mainly B-cell proliferations (P =.0058). Our data show that the inverse correlation is not confined to a particular CA autoantibody specificity. The results are discussed in the light of recent findings showing that anti-IgM Abs may either inactivate or kill tumoral B cells by apoptosis.