Desmosine-inspired cross-linkers for hyaluronan hydrogels

• Verfasst von: Hagel, Valentin [VerfasserIn]
• Verfasst von: Wegner, Seraphine V. [VerfasserIn]
• Verfasst von: Nuss, Isabell [VerfasserIn]
• Verfasst von: Haraszti, Tamás [VerfasserIn]
• Verfasst von: Spatz, Joachim P. [VerfasserIn]
• Verfasst von: Böhm, Heike [VerfasserIn]
• Titel: Desmosine-inspired cross-linkers for hyaluronan hydrogels
• Verf.angabe: Valentin Hagel, Markus Mateescu, Alexander Southan, Seraphine V. Wegner, Isabell Nuss, Tamás Haraszti, Claudia Kleinhans, Christian Schuh, Joachim P. Spatz, Petra J. Kluger, Monika Bach, Stefan Tussetschläger, Günter E. M. Tovar, Sabine Laschat & Heike Boehm
• E-Jahr: 2013
• Jahr: 20 June 2013
• Umfang: 5 S.
• Fussnoten: Gesehen am 23.02.2021
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2013
• Band/Heft Quelle: 3(2013) Artikel-Nummer 2043, 5 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/srep02043
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1749059428

Abstract

We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-synthetic hydrogels are form-stable, can withstand repeated stress, have a large linear-elastic range and show strain stiffening behavior typical for biopolymer networks. In addition, it is possible to introduce a positive charge to the core of the cross-linker without affecting the gelation efficiency, or consequently the network connectivity. However, the mechanical properties strongly depend on the charge of the cross-linker. The properties of the presented hydrogels can thus be tuned in a range important for engineering of soft tissues by controlling the cross-linking density and the charge of the cross-linker.