| |  Online-Ressource |
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| Verfasst von: | Eibert, Sybille M. [VerfasserIn]  |
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| | Lee, Kyeong-Hee [VerfasserIn] |
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| | Pipkorn, Rüdiger [VerfasserIn] |
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| | Sester, Urban [VerfasserIn] |
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| | Wabnitz, Guido H. [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| | Meuer, Stefan [VerfasserIn] |
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| | Samstag, Yvonne [VerfasserIn] |
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| Titel: | Cofilin peptide homologs interfere with immunological synapse formation and T cell activation |
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| Verf.angabe: | Sybille M. Eibert, Kyeong-Hee Lee, Rüdiger Pipkorn, Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, and Yvonne Samstag |
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| E-Jahr: | 2004 |
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| Jahr: | February 3, 2004 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 22.02.2021 |
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| Titel Quelle: | Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America |
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| Ort Quelle: | Washington, DC : National Acad. of Sciences, 1915 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 101(2004), 7, Seite 1957-1962 |
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| ISSN Quelle: | 1091-6490 |
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| Abstract: | The formation of supramolecular activation clusters within the immunological synapse, crucial for sustained signaling and T lymphocyte activation, requires costimulation-dependent reorganization of the actin cytoskeleton. Here we have identified the actin-remodeling protein cofilin as a key player in this process. Cell-permeable peptides that block costimulation-induced cofilin/F-actin interactions in untransformed human T lymphocytes impair receptor capping and immunological synapse formation at the interface between T cells and antigen-presenting cells. As a consequence, T cell activation, as measured by cytokine production and proliferation, is inhibited. |
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| DOI: | doi:10.1073/pnas.0308282100 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1073/pnas.0308282100 |
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| | Volltext: https://www.pnas.org/content/101/7/1957 |
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| | DOI: https://doi.org/10.1073/pnas.0308282100 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Actin Depolymerizing Factors |
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| | Actins |
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| | Antigen-Presenting Cells |
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| | Carrier Proteins |
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| | CD2 Antigens |
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| | Cell Division |
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| | Cell Line, Tumor |
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| | Cell Membrane Permeability |
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| | Cell-Penetrating Peptides |
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| | Cells, Cultured |
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| | Cytokines |
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| | Humans |
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| | Immunologic Capping |
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| | Isoantigens |
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| | Lymphocyte Activation |
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| | Microfilament Proteins |
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| | Peptides |
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| | Protein Binding |
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| | T-Lymphocytes |
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| | Th1 Cells |
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| | Th2 Cells |
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| K10plus-PPN: | 174906099X |
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| Verknüpfungen: | → Zeitschrift |
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Cofilin peptide homologs interfere with immunological synapse formation and T cell activation / Eibert, Sybille M. [VerfasserIn]; February 3, 2004 (Online-Ressource)
