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| Verfasst von: | Nebl, Gabriele [VerfasserIn]  |
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| | Fischer, Sabine [VerfasserIn] |
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| | Penzel, Roland [VerfasserIn] |
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| | Samstag, Yvonne [VerfasserIn] |
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| Titel: | Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K |
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| Verf.angabe: | Gabriele Nebl, Sabine Fischer, Roland Penzel, Yvonne Samstag |
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| Jahr: | 2004 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 22.02.2021 |
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| Titel Quelle: | Enthalten in: Cellular signalling |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1989 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 16(2004), 2, Seite 235-243 |
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| ISSN Quelle: | 1873-3913 |
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| Abstract: | Remodeling of the actin cytoskeleton is crucial for a multitude of cellular functions including cell movement, intracellular transport as well as signal transduction and gene expression processes. Cofilin has been identified as a key mediator of actin reorganization. Its activity is regulated via reversible phosphorylation of ser-3. In a variety of cell types stimulation through particular surface receptors fastly induces the dephosphorylation/activation of cofilin. Yet, the signal transduction cascades linking receptor stimulation with cofilin activation have not been identified so far. Here we show that the GTPase Ras acts as a central regulator of the cofilin dephosphorylation pathway. Thus, stimulation of Ras through platelet-derived growth factor (PDGF) or transient expression of activated Ras-proteins induces the dephosphorylation of cofilin. Importantly, the cooperation of two Ras-initiated signaling pathways is required to induce cofilin dephosphorylation: a Ras-Raf-MAPkinase/Erk-kinase (MEK)- and a Ras-phosphatidylinositol-3-kinase (PI3K)-effector cascade. |
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| DOI: | doi:10.1016/s0898-6568(03)00133-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1016/s0898-6568(03)00133-5 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0898656803001335 |
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| | DOI: https://doi.org/10.1016/s0898-6568(03)00133-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Actin Depolymerizing Factors |
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| | Actins |
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| | Animals |
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| | Cytoskeleton |
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| | Enzyme Inhibitors |
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| | MAP Kinase Kinase Kinase 1 |
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| | MAP Kinase Kinase Kinases |
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| | Mice |
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| | Microfilament Proteins |
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| | NIH 3T3 Cells |
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| | Phosphatidylinositol 3-Kinases |
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| | Phosphoinositide-3 Kinase Inhibitors |
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| | Phosphorylation |
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| | Platelet-Derived Growth Factor |
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| | Proto-Oncogene Proteins c-raf |
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| | ras Proteins |
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| | Signal Transduction |
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| K10plus-PPN: | 1749064723 |
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| Verknüpfungen: | → Zeitschrift |
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Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K / Nebl, Gabriele [VerfasserIn]; 2004 (Online-Ressource)
