| |  Online-Ressource |
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| Verfasst von: | Cordes, Frank [VerfasserIn]  |
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| | Kraiczy, Peter [VerfasserIn] |
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| | Roversi, Pietro [VerfasserIn] |
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| | Skerka, Christine [VerfasserIn] |
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| | Kirschfink, Michael [VerfasserIn] |
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| | Simon, Markus M. [VerfasserIn] |
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| | Brade, Volker [VerfasserIn] |
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| | Lowe, Edward D. [VerfasserIn] |
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| | Zipfel, Peter F. [VerfasserIn] |
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| | Wallich, Reinhard [VerfasserIn] |
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| | Lea, Susan M. [VerfasserIn] |
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| Titel: | Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi |
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| Verf.angabe: | Frank S. Cordes, Peter Kraiczy, Pietro Roversi, Christine Skerka, Michael Kirschfink, Markus M. Simon, Volker Brade, Edward D. Lowe, Peter Zipfel, Reinhard Wallich and Susan M. Lea |
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| Jahr: | 2004 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 26.02.2021 |
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| Titel Quelle: | Enthalten in: Acta crystallographica / D |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1993 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 60(2004), 5, Seite 929-932 |
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| ISSN Quelle: | 0907-4449 |
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| Abstract: | Borrelia burgdorferi is the causative agent of Lyme disease. Serum-resistant strains of the pathogen are able to reduce the host's immune response to infection by recruiting fluid-phase complement regulators from the serum. B. burgdorferi complement regulator-acquiring surface protein-1 (BbCRASP-1) binds factor H and factor-H-like protein-1 to the bacterial surface, where they actively down-regulate complement response. Crystals of native and selenomethionine-substituted BbCRASP-1 have been obtained and a native data set to 2.7 A as well as selenomethionine MAD data to 3.2 A resolution have been collected. The selenium substructure has been solved and initial phases have been refined to 3.0 A by density-modification methods. Model building and refinement are under way. |
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| DOI: | doi:10.1107/S090744490400472X |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://dx.doi.org/10.1107/S090744490400472X |
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| | DOI: https://doi.org/10.1107/S090744490400472X |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bacterial Proteins |
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| | Binding Sites |
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| | Borrelia burgdorferi |
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| | Crystallization |
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| | Crystallography, X-Ray |
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| | Escherichia coli |
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| | Membrane Proteins |
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| | Protein Conformation |
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| | Recombinant Proteins |
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| | Selenium |
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| | Selenomethionine |
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| K10plus-PPN: | 1749525267 |
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| Verknüpfungen: | → Zeitschrift |
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Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi / Cordes, Frank [VerfasserIn]; 2004 (Online-Ressource)
