| Online-Ressource |
Verfasst von: | Cordes, Frank [VerfasserIn]  |
| Kraiczy, Peter [VerfasserIn]  |
| Roversi, Pietro [VerfasserIn]  |
| Skerka, Christine [VerfasserIn]  |
| Kirschfink, Michael [VerfasserIn]  |
| Simon, Markus M. [VerfasserIn]  |
| Brade, Volker [VerfasserIn]  |
| Lowe, Edward D. [VerfasserIn]  |
| Zipfel, Peter F. [VerfasserIn]  |
| Wallich, Reinhard [VerfasserIn]  |
| Lea, Susan M. [VerfasserIn]  |
Titel: | Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi |
Verf.angabe: | Frank S. Cordes, Peter Kraiczy, Pietro Roversi, Christine Skerka, Michael Kirschfink, Markus M. Simon, Volker Brade, Edward D. Lowe, Peter Zipfel, Reinhard Wallich and Susan M. Lea |
Jahr: | 2004 |
Umfang: | 4 S. |
Fussnoten: | Gesehen am 26.02.2021 |
Titel Quelle: | Enthalten in: Acta crystallographica / D |
Ort Quelle: | Oxford : Wiley-Blackwell, 1993 |
Jahr Quelle: | 2004 |
Band/Heft Quelle: | 60(2004), 5, Seite 929-932 |
ISSN Quelle: | 0907-4449 |
Abstract: | Borrelia burgdorferi is the causative agent of Lyme disease. Serum-resistant strains of the pathogen are able to reduce the host's immune response to infection by recruiting fluid-phase complement regulators from the serum. B. burgdorferi complement regulator-acquiring surface protein-1 (BbCRASP-1) binds factor H and factor-H-like protein-1 to the bacterial surface, where they actively down-regulate complement response. Crystals of native and selenomethionine-substituted BbCRASP-1 have been obtained and a native data set to 2.7 A as well as selenomethionine MAD data to 3.2 A resolution have been collected. The selenium substructure has been solved and initial phases have been refined to 3.0 A by density-modification methods. Model building and refinement are under way. |
DOI: | doi:10.1107/S090744490400472X |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://dx.doi.org/10.1107/S090744490400472X |
| DOI: https://doi.org/10.1107/S090744490400472X |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Bacterial Proteins |
| Binding Sites |
| Borrelia burgdorferi |
| Crystallization |
| Crystallography, X-Ray |
| Escherichia coli |
| Membrane Proteins |
| Protein Conformation |
| Recombinant Proteins |
| Selenium |
| Selenomethionine |
K10plus-PPN: | 1749525267 |
Verknüpfungen: | → Zeitschrift |
Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi / Cordes, Frank [VerfasserIn]; 2004 (Online-Ressource)