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Verfasst von:Wallich, Reinhard [VerfasserIn]   i
 Siebers, A. [VerfasserIn]   i
 Jahraus, Oliver [VerfasserIn]   i
 Brenner, Christiane [VerfasserIn]   i
 Stehle, T. [VerfasserIn]   i
 Simon, M.M. [VerfasserIn]   i
Titel:DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but Not for resolution of Lyme disease
Verf.angabe:Reinhard Wallich, Annette Siebers, Oliver Jahraus, Christiane Brenner, Thomas Stehle, and Markus M. Simon
Jahr:2001
Umfang:7 S.
Teil:volume:69
 year:2001
 number:4
 pages:2130-2136
 extent:7
Fussnoten:Gesehen am 26.02.2021
Titel Quelle:Enthalten in: Infection and immunity
Ort Quelle:Washington, DC : Soc., 1970
Jahr Quelle:2001
Band/Heft Quelle:69(2001), 4, Seite 2130-2136
ISSN Quelle:1098-5522
Abstract:DNA vaccines encoding the outer surface protein A (OspA) of Borrelia burgdorferi have been shown to induce protective humoral responses capable of preventing but not curing infection in mice. Subsequent studies showed that an established infection or disease could be resolved by passive transfer of antibodies to OspC. In the present study, DNA vaccines encoding either the OspC antigen alone or fused to OspA and under the transcriptional control of the human elongation factor 1alpha promoter were evaluated for their protective and/or curative potential. In contrast to ospA-containing plasmids, none of the six constructs with ospC alone were immunogenic in vivo, independent of whether they contained promoter or leader sequences from ospA and/or ospC, or alternatively, the signal sequence of the human tissue plasminogen activator. Solely, a DNA vaccine encoding an OspA-OspC fusion product led to expression of the respective polypeptide chain in transfected cells in vitro and to the induction of OspA- and OspC-specific antibodies in vivo. Immune sera raised against the OspA-OspC fusion product conveyed full protection against subsequent infection, most probably via OspA-specific antibodies, but were unable to resolve infection.
DOI:doi:10.1128/IAI.69.4.2130-2136.2001
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://dx.doi.org/10.1128/IAI.69.4.2130-2136.2001
 DOI: https://doi.org/10.1128/IAI.69.4.2130-2136.2001
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Animals
 Antigens, Bacterial
 Antigens, Surface
 Bacterial Outer Membrane Proteins
 Bacterial Vaccines
 Borrelia burgdorferi Group
 Humans
 Immunization
 Lipoproteins
 Lyme Disease
 Lyme Disease Vaccines
 Mice
 Mice, Inbred BALB C
 Mice, SCID
 Tumor Cells, Cultured
 Vaccines, DNA
K10plus-PPN:174953469X
Verknüpfungen:→ Zeitschrift

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