| |  Online-Ressource |
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| Verfasst von: | Hauser, Thomas [VerfasserIn]  |
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| | Schönknecht, Peter [VerfasserIn] |
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| | Thomann, Philipp [VerfasserIn] |
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| | Gerigk, Lars [VerfasserIn] |
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| | Schröder, Johannes [VerfasserIn] |
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| | Henze, Romy [VerfasserIn] |
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| | Radbruch, Alexander [VerfasserIn] |
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| | Essig, Marco [VerfasserIn] |
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| Titel: | Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI |
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| Verf.angabe: | Thomas Hauser MD, Peter Schönknecht MD, Philipp A. Thomann MD, Lars Gerigk MD, Johannes Schröder MD, Romy Henze Ph, Alexander Radbruch MD, Marco Essig MD, PhD |
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| E-Jahr: | 2013 |
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| Jahr: | 7 May 2013 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 02.03.2021 |
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| Titel Quelle: | Enthalten in: Academic radiology |
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| Ort Quelle: | Philadelphia, PA [u.a.] : Elsevier, 1994 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 20(2013), 6, Seite 705-711 |
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| ISSN Quelle: | 1878-4046 |
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| Abstract: | Rationale and Objectives - The purpose of this study was to assess regional cerebral perfusion distribution in patients with Alzheimer disease (AD) or mild cognitive impairment (MCI) using dynamic susceptibility contrast magnetic resonance imaging. - Materials and Methods - Regional changes of perfusion were evaluated in 34 patients with AD, 51 patients with MCI, and 23 healthy controls (HCs). Using region of interest analyses, regional cerebral blood flow (CBF), cerebral blood volume, and mean transit time were measured bilaterally in the hippocampus; the temporal, temporoparietal, frontal, and sensomotoric cortices; the anterior and posterior cingulate gyri; the lentiform nucleus; and the cerebellum. - Results - A significant reduction of CBF in patients with AD compared to HCs was shown in the frontal and temporoparietal cortices bilaterally, the lentiform nuclei bilaterally, the left posterior cingulate gyrus, and the cerebellum. Compared with patients with MCI, patients with AD presented a reduction of CBF in the frontal cortices bilaterally, the left temporoparietal cortex, and the left anterior and posterior cingulate gyrus. In both hippocampi and the posterior cingulate gyrus, a trend to a slight increase of CBF in patients with MCI was noticed with a decrease in patients with AD. - Conclusions - Using dynamic susceptibility contrast magnetic resonance imaging, pathologic alterations of regional brain perfusion can be demonstrated in patients with AD compared to patients with MCI or HCs. |
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| DOI: | doi:10.1016/j.acra.2013.01.020 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.acra.2013.01.020 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1076633213001098 |
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| | DOI: https://doi.org/10.1016/j.acra.2013.01.020 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alzheimer dementia |
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| | cerebral blood flow |
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| | dynamic susceptibility contrast MRI |
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| | mild cognitive impairment |
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| | regional perfusion alteration |
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| K10plus-PPN: | 1750022133 |
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| Verknüpfungen: | → Zeitschrift |
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Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI / Hauser, Thomas [VerfasserIn]; 7 May 2013 (Online-Ressource)
