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Verfasst von:Reinink, Hendrik [VerfasserIn]   i
 Jüttler, Eric [VerfasserIn]   i
 Hacke, Werner [VerfasserIn]   i
 Hofmeijer, Jeannette [VerfasserIn]   i
 Vicaut, Eric [VerfasserIn]   i
 Vahedi, Katayoun [VerfasserIn]   i
 Slezins, Janis [VerfasserIn]   i
 Su, Yingying [VerfasserIn]   i
 Fan, Linlin [VerfasserIn]   i
 Kumral, Emre [VerfasserIn]   i
 Greving, Jacoba P. [VerfasserIn]   i
 Algra, Ale [VerfasserIn]   i
 Kappelle, L. Jaap [VerfasserIn]   i
 van der Worp, H. Bart [VerfasserIn]   i
 Neugebauer, Hermann [VerfasserIn]   i
Titel:Surgical decompression for space-occupying hemispheric infarction
Titelzusatz:a systematic review and individual patient meta-analysis of randomized clinical trials
Verf.angabe:Hendrik Reinink, Eric Jüttler, Werner Hacke, Jeannette Hofmeijer, Eric Vicaut, Katayoun Vahedi, Janis Slezins, Yingying Su, Linlin Fan, Emre Kumral, Jacoba P. Greving, Ale Algra, L. Jaap Kappelle, H. Bart van der Worp, Hermann Neugebauer
Jahr:2021
Umfang:9 S.
Fussnoten:Gesehen am 02.03.2021
Titel Quelle:Enthalten in: JAMA neurology
Ort Quelle:Chicago, Ill. : American Medical Association, 2013
Jahr Quelle:2021
Band/Heft Quelle:78(2021), 2, Seite 208-216
ISSN Quelle:2168-6157
Abstract:Importance: In patients with space-occupying hemispheric infarction, surgical decompression reduces the risk of death and increases the chance of a favorable outcome. Uncertainties, however, still remain about the benefit of this treatment for specific patient groups. Objective: To assess whether surgical decompression for space-occupying hemispheric infarction is associated with a reduced risk of death and an increased chance of favorable outcomes, as well as whether this association is modified by patient characteristics. Data Sources: MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and the Stroke Trials Registry were searched from database inception to October 9, 2019, for English-language articles that reported on the results of randomized clinical trials of surgical decompression vs conservative treatment in patients with space-occupying hemispheric infarction. Study Selection: Published and unpublished randomized clinical trials comparing surgical decompression with medical treatment alone were selected. Data Extraction and Synthesis: Patient-level data were extracted from the trial databases according to a predefined protocol and statistical analysis plan. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline and the Cochrane Collaboration's tool for assessing risk of bias were used. One-stage, mixed-effect logistic regression modeling was used for all analyses. Main Outcomes and Measures: The primary outcome was a favorable outcome (modified Rankin Scale [mRS] score ≤3) at 1 year after stroke. Secondary outcomes included death, reasonable (mRS score ≤4) and excellent (mRS score ≤2) outcomes at 6 months and 1 year, and an ordinal shift analysis across all levels of the mRS. Variables for subgroup analyses were age, sex, presence of aphasia, stroke severity, time to randomization, and involved vascular territories. Results: Data from 488 patients from 7 trials from 6 countries were available for analysis. The risk of bias was considered low to moderate for 6 studies. Surgical decompression was associated with a decreased chance of death (adjusted odds ratio, 0.16; 95% CI, 0.10-0.24) and increased chance of a favorable outcome (adjusted odds ratio, 2.95; 95% CI, 1.55-5.60), without evidence of heterogeneity of treatment effect across any of the prespecified subgroups. Too few patients were treated later than 48 hours after stroke onset to allow reliable conclusions in this subgroup, and the reported proportions of elderly patients reaching a favorable outcome differed considerably among studies. Conclusions and Relevance: The results suggest that the benefit of surgical decompression for space-occupying hemispheric infarction is consistent across a wide range of patients. The benefit of surgery after day 2 and in elderly patients remains uncertain.
DOI:doi:10.1001/jamaneurol.2020.3745
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1001/jamaneurol.2020.3745
 Volltext: https://jamanetwork.com/journals/jamaneurology/article-abstract/2771411
 DOI: https://doi.org/10.1001/jamaneurol.2020.3745
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1750142023
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