Immune escape of tumors

• Verfasst von: Igney, Frederik [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: Immune escape of tumors
• Titelzusatz: apoptosis resistance and tumor counterattack
• Verf.angabe: Frederik H. Igney and Peter H. Krammer
• E-Jahr: 2002
• Jahr: 01 June 2002
• Umfang: 14 S.
• Teil: volume:71
• Teil: year:2002
• Teil: number:6
• Teil: month:06
• Teil: pages:907-920
• Teil: extent:14
• Fussnoten: Gesehen am 02.03.2021 ; DOI funktioniert nicht
• Titel Quelle: Enthalten in: Journal of leukocyte biology
• Ort Quelle: Hoboken, NJ : Wiley, 1984
• Jahr Quelle: 2002
• Band/Heft Quelle: 71(2002), 6 vom: Juni, Seite 907-920
• ISSN Quelle: 1938-3673
• DOI: doi:10.1189/jlb.71.6.907
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CD95
• Sach-SW: CD95L
• Sach-SW: cytotoxic T cells
• Sach-SW: death receptor
• Sach-SW: immunosuppression
• K10plus-PPN: 1750154552

Abstract

Interactions between the immune system and malignant cells play an important role in tumorigenesis. Failure of the immune system to detect and reject transformed cells may lead to cancer development. Tumors use multiple mechanisms to escape from immune-mediated rejection. Many of these mechanisms are now known on a cellular and molecular level. Despite this knowledge, cancer immunotherapy is still not an established treatment in the clinic. This review discusses the immune escape mechanisms used by tumors with an emphasis on mechanisms related to apoptosis.