Regulation of T cell apoptosis during the immune response

• Verfasst von: Baumann, Sven [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: Regulation of T cell apoptosis during the immune response
• Verf.angabe: Sven Baumann, Andreas Krueger, Sabine Kirchhoff und Peter H. Krammer
• Jahr: 2002
• Umfang: 16 S.
• Teil: volume:2
• Teil: year:2002
• Teil: number:3
• Teil: pages:257-272
• Teil: extent:16
• Fussnoten: Gesehen am 03.03.2021
• Titel Quelle: Enthalten in: Current molecular medicine
• Ort Quelle: Boca Raton, Fla. [u.a.] : Bentham Science Publ., 2001
• Jahr Quelle: 2002
• Band/Heft Quelle: 2(2002), 3, Seite 257-272
• ISSN Quelle: 1875-5666
• DOI: doi:10.2174/1566524024605671
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1750181290

Abstract

Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.