Regulation of death receptor-mediated apoptosis pathways

• Verfasst von: Schmitz, Ingo [VerfasserIn]
• Verfasst von: Kirchhoff, Sabine [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: Regulation of death receptor-mediated apoptosis pathways
• Verf.angabe: Ingo Schmitz, Sabine Kirchhoff, Peter H Krammer
• E-Jahr: 2000
• Jahr: 21 December 2000
• Umfang: 14 S.
• Teil: volume:32
• Teil: year:2000
• Teil: number:11/12
• Teil: pages:1123-1136
• Teil: extent:14
• Fussnoten: Gesehen am 03.03.2021
• Titel Quelle: Enthalten in: International journal of biochemistry & cell biology
• Ort Quelle: Amsterdam : Elsevier, 1995
• Jahr Quelle: 2000
• Band/Heft Quelle: 32(2000), 11/12, Seite 1123-1136
• ISSN Quelle: 1878-5875
• DOI: doi:10.1016/S1357-2725(00)00048-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Apoptosis
• Sach-SW: Caspases
• Sach-SW: CD95
• Sach-SW: Death receptors
• Sach-SW: FLIP
• K10plus-PPN: 1750196832

Abstract

Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the cell type, signalling pathways downstream of the death receptors can be modulated by different proteins such as Bcl-2, FLIPs, chaperones and kinases. Deregulation of apoptosis has been associated with diseases as cancer, autoimmunity and AIDS. Therefore, the identification of modulators of apoptosis has several therapeutic implications.